Pre_GI Island

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n1_4mer:GRV/n1_4mer:RV = (Global Relative Variance of OU patterns) / (Local Relative Variance of OU patterns)

n0_4mer:D = Distance between local and global OU patterns

n0_4mer:PS = Distance between 2 strands of same DNA molecule

Selected loci indicated by large D, increased GRV associated with decreased RV and moderate increase in PS




NC_017265: Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

NCBI: NC_017265

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.



Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

#StartEndLengthIsland TextGRV_RVDPSNeighboursClusterSub ClusterBLASTNKey Word ConfirmationOther DB ConfirmationDownload Island
1644384*66551321130Island text1.4483936.113854.623Neighbours41BLASTN644384.gbk
280994384266932727Island text1.6268335.59551.9897Neighbours41BLASTN809943.gbk
3854492*88101726526Island text1.9147329.146423.2164Neighbours41BLASTN+854492.gbk
41000342103559935258Island text1.9003432.64127.6584Neighbours41BLASTN+1000342.gbk
51136000116114425145Island text2.4494334.033529.4433Neighbours41BLASTN+1136000.gbk
61346685136472618042Island text4.465438.6823.3341Neighbours41BLASTN+1346685.gbk
71521276154409922824Island text2.0735335.193637.2944Neighbours51BLASTN1521276.gbk
81571305161059939295Island text1.5811729.249827.3298Neighbours41BLASTN+1571305.gbk
91715035173876123727Island text1.6366333.520855.762Neighbours41BLASTN+1715035.gbk
101765399178715721759Island text1.6029833.366135.9004Neighbours41BLASTN+1765399.gbk
112087487*210965322167Island text1.6028729.219436.3564Neighbours41BLASTN+2087487.gbk
122213500*223609922600Island text1.7137930.65642.3458Neighbours41BLASTN2213500.gbk
132263347228291219566Island text1.845731.767529.4325Neighbours41BLASTN+2263347.gbk
142306500*232521218713Island text1.8385832.093436.8564Neighbours41BLASTN+2306500.gbk
152557476258331725842Island text1.5509629.263129.5286Neighbours53BLASTN+2557476.gbk
162586729262042933701Island text1.5408930.064422.6885Neighbours41BLASTN+2586729.gbk
172807302283159624295Island text2.418431.190423.8945Neighbours41BLASTN+2807302.gbk
182940539*296008919551Island text1.8727632.69129.8574Neighbours41BLASTN+2940539.gbk
193063016308359920584Island text1.6991932.192829.8265Neighbours41BLASTN+3063016.gbk
203240379327635735979Island text1.8906529.027822.6824Neighbours41BLASTN+3240379.gbk
213375463339749222030Island text1.6681229.593728.7936Neighbours41BLASTN+3375463.gbk
223724500375189627397Island text4.1203737.883726.2644Neighbours41BLASTN+3724500.gbk
233790750380974518996Island text2.1627231.595928.9188Neighbours41BLASTN3790750.gbk
243821890384538723498Island text2.2574333.588720.3913BLASTN+3821890.gbk
253861259*387993618678Island text1.4945831.924934.8094Neighbours41BLASTN3861259.gbk
263982020400009918080Island text1.6298531.610438.7158Neighbours41BLASTN+3982020.gbk
274065625*408905923435Island text1.6750729.079519.6126Neighbours41BLASTN+4065625.gbk
284171500419272221223Island text1.6215928.489829.2362Neighbours53BLASTN+4171500.gbk
294265659428735621698Island text1.9387834.693920.1754Neighbours51BLASTN4265659.gbk