Pre_GI Gene

Some Help

Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:2087487 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
20874872088476990hypothetical proteinBLASTP
20886842088923240hypothetical proteinBLASTP
20890332089422390hypothetical proteinBLASTP
20896902089815126Nonribosomal peptide synthetasepolyketidesynthaseQuickGO ontologyBLASTP
208982920908511023transposaseQuickGO ontologyBLASTP
20908482091630783transposaseQuickGO ontologyBLASTP
20919992092589591thymidine kinasedeoxyuridine kinaseQuickGO ontologyBLASTP
20929462093083138hypothetical proteinBLASTP
20933392093746408global DNA-binding transcriptional dual regulator H-NSQuickGO ontologyBLASTP
209583520968511017response regulator of RpoSQuickGO ontologyBLASTP
20981852098649465hypothetical proteinBLASTP
20987332099602870Formyltetrahydrofolate deformylaseQuickGO ontologyBLASTP
209956521007731209putative transposaseQuickGO ontologyBLASTP
2101053210113785tRNA-TyrQuickGO ontologyBLASTP
21016452102505861putative LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
21028772103005129hypothetical proteinBLASTP
21033152104121807exonuclease IIIQuickGO ontologyBLASTP
21042192104605387putative pyrophosphohydrolaseQuickGO ontologyBLASTP
21046182104908291hypothetical proteinBLASTP
21047632104930168hypothetical protein
210490521068301926DNA topoisomerase IIIQuickGO ontologyBLASTP
210689221079381047selenide water dikinaseQuickGO ontologyBLASTP
21079752108133159hypothetical proteinBLASTP
21081632108714552putative oxidoreductaseQuickGO ontologyBLASTP