Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:2940539 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
29404552940583129hypothetical protein
294053929422511713D-lactate dehydrogenaseQuickGO ontologyBLASTP
29423722943307936Murein-DD-endopeptidaseQuickGO ontologyBLASTP
29432312943377147hypothetical protein
29436462943825180hypothetical protein
29438992944837939tRNA-dihydrouridine synthase CQuickGO ontologyBLASTP
29451372946066930hypothetical protein
29464812946990510transposaseQuickGO ontologyBLASTP
294715029481541005putative ATP-dependent RNA helicaseQuickGO ontologyBLASTP
29480692948659591putative transposaseQuickGO ontologyBLASTP
294875129499591209putative transposaseQuickGO ontologyBLASTP
29499632950685723hypothetical proteinBLASTP
29506822951077396hypothetical proteinBLASTP
29511412951536396hypothetical proteinBLASTP
29515742951993420hypothetical proteinBLASTP
29520572952404348hypothetical proteinBLASTP
29524862952965480hypothetical proteinBLASTP
29531252953634510transposaseQuickGO ontologyBLASTP
295395829555351578GMP synthaseQuickGO ontologyBLASTP
29555122955643132hypothetical proteinBLASTP
295571529571781464IMP dehydrogenaseQuickGO ontologyBLASTP
295734829587271380exonuclease VII large subunitQuickGO ontologyBLASTP
29588602959084225hypothetical proteinBLASTP
29591332960089957putative AEC family malate permeaseQuickGO ontologyBLASTP