Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:1765399 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
17653991766181783transposaseQuickGO ontologyBLASTP
176617817672001023transposaseQuickGO ontologyBLASTP
176774017704152676NADP-dependent alcohol dehydrogenaseQuickGO ontologyBLASTP
17712221771866645hypothetical proteinBLASTP
177270417743411638periplasmic oligopeptide-binding proteinQuickGO ontologyBLASTP
17744281775348921oligopeptide transporter subunit membrane component of ABC superfamilyQuickGO ontologyBLASTP
17753671776272906oligopeptide transport system permeaseQuickGO ontologyBLASTP
177628417772851002oligopeptide transporter subunit ATP-binding component of ABC superfamilyQuickGO ontologyBLASTP
177728217782831002ATP-binding subunit of oligopeptide ABC transporterQuickGO ontologyBLASTP
17788441779059216hypothetical proteinBLASTP
17793591779682324putative double-stranded DNA mimicQuickGO ontologyBLASTP
177984717813071461cardiolipin synthase 1QuickGO ontologyBLASTP
17811291781338210hypothetical protein
17813761781624249hypothetical proteinBLASTP
17823541782893540attachment invasion locus proteinQuickGO ontologyBLASTP
17828681782996129hypothetical proteinBLASTP
17831141783377264hypothetical proteinBLASTP
17834931783747255hypothetical proteinBLASTP
17839611784257297hypothetical proteinBLASTP
17845581785316759TonB proteinQuickGO ontologyBLASTP
178535217865601209putative transposaseQuickGO ontologyBLASTP
17867081787157450esteraseQuickGO ontologyBLASTP