Pre_GI Gene

Some Help

Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:2306500 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
230651723075301014putative oxidoreductaseQuickGO ontologyBLASTP
23079382308222285hypothetical protein
23081922308989798GntR family transcriptional regulatorQuickGO ontologyBLASTP
23090062309167162hypothetical proteinBLASTP
23091762309307132transposaseQuickGO ontologyBLASTP
23093342309540207Integrase catalytic regionQuickGO ontologyBLASTP
23099582310392435hypothetical proteinBLASTP
23104042310973570hypothetical proteinBLASTP
23113912311729339putative transposaseQuickGO ontologyBLASTP
23117292312589861putative transposaseQuickGO ontologyBLASTP
231263723137131077hypothetical proteinBLASTP
23137792314069291hypothetical proteinBLASTP
23140502314322273hypothetical proteinBLASTP
23143532314712360phage-like proteinQuickGO ontologyBLASTP
23147092315008300phage-like proteinQuickGO ontologyBLASTP
23150252315312288hypothetical proteinBLASTP
23157472315962216hypothetical proteinBLASTP
23159592316264306hypothetical proteinBLASTP
23162452316523279hypothetical proteinBLASTP
23166882316828141putative major tail sheath proteinQuickGO ontologyBLASTP
23169392317358420hypothetical proteinBLASTP
23174302318389960putative transposaseQuickGO ontologyBLASTP
23186092318953345hypothetical proteinBLASTP
23189792319194216hypothetical protein
23200162320162147hypothetical proteinBLASTP
23205312320758228Replicative DNA helicaseQuickGO ontologyBLASTP
23208692321384516IntegraseQuickGO ontologyBLASTP
23212722321541270hypothetical proteinBLASTP
2321682232176786tRNA-LeuQuickGO ontologyBLASTP
2321778232185174tRNA-CysQuickGO ontologyBLASTP
2321904232197976tRNA-GlyQuickGO ontology
23221242322672549CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferaseQuickGO ontologyBLASTP
232273123245631833excinuclease ABC subunit CQuickGO ontologyBLASTP
23245562325212657response regulator proteinQuickGO ontologyBLASTP