Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:3063016 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
306301630646591644phosphoglucomutaseQuickGO ontologyBLASTP
30647323065259528regulatory protein for replication initiationQuickGO ontologyBLASTP
30657543066122369hypothetical proteinBLASTP
30662343066410177hypothetical proteinBLASTP
30664173067178762Cellobiose phosphotransferase system YdjC-likeproteinQuickGO ontologyBLASTP
30672303068060831cel operon repressorQuickGO ontologyBLASTP
30681093068456348PTS system cellobiose-specific transporter subunit IIAQuickGO ontologyBLASTP
306862330699841362PTS system cellobiose-specific transporter subunit IICQuickGO ontologyBLASTP
30699953070312318PTS system cellobiose-specific transporter subunit IIBQuickGO ontologyBLASTP
30710853071264180hypothetical proteinBLASTP
30713533071733381hypothetical proteinBLASTP
30717493072153405hypothetical proteinBLASTP
307225130734261176putative potassium channel proteinQuickGO ontologyBLASTP
30740443074373330hypothetical proteinBLASTP
307454230756001059putative nickel transport proteinQuickGO ontologyBLASTP
30757493076741993putative urea transporterQuickGO ontologyBLASTP
30778963078558663urease accessory proteinQuickGO ontologyBLASTP
30786853079371687urease accessory proteinQuickGO ontologyBLASTP
30793933080088696urease accessory proteinQuickGO ontologyBLASTP
308038430821021719urease alpha subunitQuickGO ontologyBLASTP
30821923082626435urease subunit betaQuickGO ontologyBLASTP
30826793082981303urease subunit gammaQuickGO ontologyBLASTP