Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:3861259 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
38604483861266819dimethyladenosine transferaseQuickGO ontologyBLASTP
386125938622549964-hydroxy-L-threonine phosphate dehydrogenaseQuickGO ontologyBLASTP
386223838635421305peptidyl-prolyl cis-trans isomerase CQuickGO ontologyBLASTP
386361038659522343exported protein required for envelope biosynthesis and integrityQuickGO ontologyBLASTP
38661373866970834DnaJ-like membrane chaperone proteinQuickGO ontologyBLASTP
38672683867888621Ribosomal large subunit pseudouridine synthase AQuickGO ontologyBLASTP
38691113869854744hypothetical proteinBLASTP
387018438711971014hypothetical proteinBLASTP
38712083871768561hypothetical proteinBLASTP
387176838732791512hypothetical proteinBLASTP
38734423873960519hypothetical proteinBLASTP
38740343874477444hypothetical proteinBLASTP
387451038763541845hypothetical proteinBLASTP
38763473877330984hypothetical proteinBLASTP
387733338799362604ClpB proteinQuickGO ontologyBLASTP