Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:4171500 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
417212241740771956p-hydroxybenzoic acid efflux pump subunit AaeBQuickGO ontologyBLASTP
41740794175014936p-hydroxybenzoic acid efflux pump subunit AaeAQuickGO ontologyBLASTP
41750224175225204membrane protein of efflux systemQuickGO ontologyBLASTP
4175167417525993hypothetical protein
41755284176439912LysR family transcriptional regulatorQuickGO ontologyBLASTP
41767004177566867putative lysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
41777274177888162hypothetical proteinBLASTP
417780241803032502insecticidal toxin complex subunit proteinQuickGO ontologyBLASTP
418034441839373594insecticidal toxin complex subunit proteinQuickGO ontologyBLASTP
418399441884844491insecticidal toxin complex proteinQuickGO ontologyBLASTP
41886184188920303putative phage-like proteinQuickGO ontologyBLASTP
41889334189334402putative phage-like proteinQuickGO ontologyBLASTP
41893314189690360hypothetical proteinBLASTP
418989141927222832insecticidal toxin complex proteinQuickGO ontologyBLASTP