Pre_GI Gene

Some Help

Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:4065625 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
40656254066161537hypothetical proteinBLASTP
406686740680631197thymidylate kinaseQuickGO ontologyBLASTP
406807440691201047M48 peptidase family proteinQuickGO ontologyBLASTP
40691294069254126hypothetical proteinBLASTP
406926640704201155hypothetical proteinBLASTP
407041740718051389hypothetical proteinBLASTP
40720474072244198hypothetical proteinBLASTP
40724464072733288hypothetical proteinBLASTP
407307740744501374hypothetical proteinBLASTP
40744224075144723DNA mismatch repair proteinQuickGO ontologyBLASTP
407519440765191326modification methylaseQuickGO ontologyBLASTP
40766584076921264transposaseQuickGO ontologyBLASTP
40769474077141195transposaseQuickGO ontologyBLASTP
40772464077476231hypothetical proteinBLASTP
407754340788591317hypothetical proteinBLASTP
407885640809192064hypothetical proteinBLASTP
408105340820751023transposaseQuickGO ontologyBLASTP
40820724082854783transposaseQuickGO ontologyBLASTP
40829284083365438D-Tyr-tRNATyr deacylaseQuickGO ontologyBLASTP
40833724084256885Ribonuclease BNQuickGO ontologyBLASTP
40843534084943591phosphataseQuickGO ontologyBLASTP
408526540870881824GTP-binding proteinQuickGO ontologyBLASTP
408765040890591410glutamine synthetaseQuickGO ontologyBLASTP