Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:3724500 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
372453337256121080periplasmic binding proteinQuickGO ontologyBLASTP
372582437269301107Fimbrial proteinQuickGO ontologyBLASTP
37269553727674720fimbrial chaperone proteinQuickGO ontologyBLASTP
372769237301722481outer membrane usher proteinQuickGO ontologyBLASTP
37305253731034510transposaseQuickGO ontologyBLASTP
37311833731605423Type IV prepilin peptidase TadVCpaAQuickGO ontologyBLASTP
37316573732523867Flp pilus assembly protein RcpCCpaBQuickGO ontologyBLASTP
37325203733374855Type IIIV secretion system secretin RcpACpaCassociated with Flp pilus assemblyQuickGO ontologyBLASTP
37333893733838450Type IIIV secretion system secretin RcpACpaCassociated with Flp pilus assemblyQuickGO ontologyBLASTP
373413637352631128Type IIIV secretion system ATPase TadZCpaEassociated with Flp pilus assemblyQuickGO ontologyBLASTP
373527537365611287Type IIIV secretion system ATP hydrolaseTadAVirB11CpaF TadA subfamilyQuickGO ontologyBLASTP
37365583737433876Flp pilus assembly protein TadBQuickGO ontologyBLASTP
37374303738263834Type IIIV secretion system protein TadCassociated with Flp pilus assemblyQuickGO ontologyBLASTP
37382473739017771Flp pilus assembly protein TadD contains TPRrepeatQuickGO ontologyBLASTP
37390173739487471Flp pilus assembly membrane protein TadEQuickGO ontologyBLASTP
37394713740043573hypothetical proteinBLASTP
374006837416241557putative fimbrial anchorQuickGO ontologyBLASTP
37417213742152432membrane spanning protein in TonB-ExbB-ExbD complexQuickGO ontologyBLASTP
374215637431931038membrane spanning protein in TonB-ExbB-ExbD complexQuickGO ontologyBLASTP
374367237448831212cystathionine beta-lyaseQuickGO ontologyBLASTP
37450763745738663hypothetical proteinBLASTP
37458303746723894putative DNA-binding transcriptional regulatorQuickGO ontologyBLASTP
374712137482781158NADP-dependent alcohol dehydrogenaseQuickGO ontologyBLASTP
37483413748550210hypothetical proteinBLASTP
3748697374953083425-diketo-D-gluconate reductase AQuickGO ontologyBLASTP
37495523750364813hypothetical proteinBLASTP
375034937518961548Fe-S OxidoreductaseQuickGO ontologyBLASTP