Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:2213500 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
22141732214865693Cytoplasmic copper homeostasis protein cutCQuickGO ontologyBLASTP
22149972215101105hypothetical protein
22151702215745576putative metal-binding enzymeQuickGO ontologyBLASTP
22157662215894129hypothetical proteinBLASTP
22157752215921147hypothetical proteinBLASTP
221636022180901731arginyl-tRNA synthetaseQuickGO ontologyBLASTP
221832122230514731putative hemolysinQuickGO ontologyBLASTP
222308122247421662putative hemolysin activator proteinQuickGO ontologyBLASTP
222522222267571536putative inner membrane proteinQuickGO ontologyBLASTP
22270242227878855hypothetical proteinBLASTP
22278142228635822hypothetical proteinBLASTP
22286432229227585ribosomal-protein-S5-alanine N-acetyltransferaseQuickGO ontologyBLASTP
222952122307261206putative drug efflux systemQuickGO ontologyBLASTP
22308732230980108hypothetical proteinBLASTP
22311212231684564putative lipoproteinQuickGO ontologyBLASTP
2231735223182793hypothetical protein
22317982231908111hypothetical proteinBLASTP
22319552232065111hypothetical proteinBLASTP
22321382232698561hypothetical proteinBLASTP
22327352233472738putative zinc-binding hydrolaseQuickGO ontologyBLASTP
2233761223385090tRNA-SerQuickGO ontologyBLASTP
223410722352221116transcriptional regulatorQuickGO ontologyBLASTP
22352362236066831glycerophosphoryl diester phosphodiesteraseQuickGO ontologyBLASTP