Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:644384 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
644384644941558anaerobic dimethyl sulfoxide reductase subunit BQuickGO ontologyBLASTP
6449646469792016putative oxidoreductaseQuickGO ontologyBLASTP
647399647974576putative transcriptional regulatorQuickGO ontologyBLASTP
64811964819476tRNA-PheQuickGO ontologyBLASTP
6486286511832556Enhancing factorQuickGO ontologyBLASTP
651213651380168hypothetical proteinBLASTP
651610652035426hypothetical proteinBLASTP
652098652400303Insertion element iso-IS1n protein insBQuickGO ontologyBLASTP
652471652737267hypothetical proteinBLASTP
6528916539251035L-rhamnose-proton symporterQuickGO ontologyBLASTP
653900654049150hypothetical proteinBLASTP
654074654946873AraC family transcriptional regulatorQuickGO ontologyBLASTP
654970655101132hypothetical proteinBLASTP
655079655900822transcriptional activator RhaSQuickGO ontologyBLASTP
656122656304183hypothetical proteinBLASTP
6563276577841458rhamnulokinaseQuickGO ontologyBLASTP
6577816590371257L-rhamnose isomeraseQuickGO ontologyBLASTP
659050659874825rhamnulose-1-phosphate aldolaseQuickGO ontologyBLASTP
6599416610891149putative alcohol dehydrogenaseQuickGO ontologyBLASTP
661103661417315L-rhamnose mutarotaseQuickGO ontologyBLASTP
661664662212549ssDNA-binding proteinQuickGO ontologyBLASTP
6626706655132844ATPase and DNA damage recognition protein of nucleotide excision repair excinuclease UvrABCQuickGO ontologyBLASTP