Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:854492 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
8523558544992145putative hydroxamate-type ferrisiderophore receptorQuickGO ontologyBLASTP
854492855463972putative solute-binding periplasmic protein ofABC transporterQuickGO ontologyBLASTP
8558928569801089membrane-bound lytic murein transglycosylase CQuickGO ontologyBLASTP
857151857423273iron-sulfur cluster protector proteinQuickGO ontologyBLASTP
8576018587161116adenine DNA glycosylaseQuickGO ontologyBLASTP
859054859773720tRNA guanine-N7--methyltransferaseQuickGO ontologyBLASTP
859773860099327hypothetical proteinBLASTP
860210861136927putative glutaminaseQuickGO ontologyBLASTP
8624778718099333putative virulence determinantQuickGO ontologyBLASTP
8719998731291131putative oxidoreductaseQuickGO ontologyBLASTP
873122873715594dITPXTP pyrophosphataseQuickGO ontologyBLASTP
873815874105291hypothetical proteinBLASTP
874102874656555putative inner membrane proteinQuickGO ontologyBLASTP
874944875765822putative pyrroline-5-carboxylate reductaseQuickGO ontologyBLASTP
875898876596699hypothetical proteinBLASTP
8766168777401125putative transporterQuickGO ontologyBLASTP
8778498789641116Agmatine deiminaseQuickGO ontologyBLASTP
878968879852885putative carbon-nitrogen hydrolaseQuickGO ontologyBLASTP
880032880454423putative Holliday junction resolvaseQuickGO ontologyBLASTP
880454881017564hypothetical proteinBLASTP