Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:2807302 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
280730228090021701PTS system fructose-specific transporter subunit IIBCQuickGO ontologyBLASTP
28090172809955939fructose-1-phosphate kinaseQuickGO ontologyBLASTP
280995228110851134IIA and HPr components of fructose-specific PTS enzymeQuickGO ontologyBLASTP
28110982811238141hypothetical proteinBLASTP
28113472811802456putative Mut family proteinQuickGO ontologyBLASTP
28119152812913999putative ABC transport integral membrane subunitQuickGO ontologyBLASTP
28129492813614666D-xylose transport ATP-binding protein xylGQuickGO ontologyBLASTP
281333128145241194sugar transport ATP-binding proteinQuickGO ontologyBLASTP
2814481281457999hypothetical proteinBLASTP
281463328157211089putative periplasmic carbohydrate-binding transport proteinQuickGO ontologyBLASTP
28158452816555711putative ribose 5-phosphate isomeraseQuickGO ontologyBLASTP
281657528181281554putative carbohydrate kinaseQuickGO ontologyBLASTP
281813228196281497putative aldehyde dehydrogenaseQuickGO ontologyBLASTP
281998028211221143hypothetical proteinBLASTP
28211192822084966putative D-isomer specific 2-hydroxyacid dehydrogenase family proteinQuickGO ontologyBLASTP
28220952822910816putative short chain oxidoreductaseQuickGO ontologyBLASTP
28229792823233255hypothetical proteinBLASTP
282360828248521245putative tryptophan-specific transport proteinQuickGO ontologyBLASTP
28249562825528573Translation elongation factor P-relatedproteinQuickGO ontologyBLASTP
282566828268611194mannonate hydrolaseQuickGO ontologyBLASTP
2827135282722793hypothetical protein
282744628289181473putative D-mannonate oxidoreductaseQuickGO ontologyBLASTP
28290622829862801DNA-binding transcriptional repressorQuickGO ontologyBLASTP
28306132831596984hypothetical proteinBLASTP