Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:1521276 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
15212761522208933LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
15223541522488135hypothetical protein
15228861523386501NADHubiquinone oxidoreductase membrane subunit AQuickGO ontologyBLASTP
15234881524165678NADHubiquinone oxidoreductase subunit BQuickGO ontologyBLASTP
152430615261021797NADHubiquinone oxidoreductase chain CDQuickGO ontologyBLASTP
15261051526668564NADHubiquinone oxidoreductase subunit EQuickGO ontologyBLASTP
152666515280501386NADHubiquinone oxidoreductase subunit FQuickGO ontologyBLASTP
152813715308812745NADHubiquinone oxidoreductase subunit GQuickGO ontologyBLASTP
15308781531855978NADHubiquinone oxidoreductase membrane subunit HQuickGO ontologyBLASTP
15318701532412543NADHubiquinone oxidoreductase subunit IQuickGO ontologyBLASTP
15324251532970546NADHubiquinone oxidoreductase membrane subunit JQuickGO ontologyBLASTP
15329671533269303NADHubiquinone oxidoreductase membrane subunit KQuickGO ontologyBLASTP
153326615351101845NADHubiquinone oxidoreductase membrane subunit LQuickGO ontologyBLASTP
153515015366821533NADHubiquinone oxidoreductase membrane subunit MQuickGO ontologyBLASTP
153668915381521464NADHubiquinone oxidoreductase membrane subunit NQuickGO ontologyBLASTP
153838815395781191hypothetical proteinBLASTP
15399391540406468hypothetical proteinBLASTP
15404841541020537putative thermosensitive gluconokinaseQuickGO ontologyBLASTP
15410691541833765gluconate 5-dehydrogenaseQuickGO ontologyBLASTP
15418361542003168hypothetical proteinBLASTP
15423161542438123hypothetical proteinBLASTP
154259215438751284putative lipoproteinQuickGO ontologyBLASTP