Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:1715035 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
171503517160451011putative Zinc-binding dehydrogenaseQuickGO ontologyBLASTP
171645217196523201beta-galactosidaseQuickGO ontologyBLASTP
17201931720405213cold shock proteinQuickGO ontologyBLASTP
17206201720811192hypothetical proteinBLASTP
17238541724552699Mg2 transport ATPase protein CQuickGO ontologyBLASTP
172495317260201068Mg2 transport ATPase P-typeQuickGO ontologyBLASTP
172598717276511665Mg2 transport ATPase protein BQuickGO ontologyBLASTP
17291941729697504Flagellar transcriptional activator flhCQuickGO ontologyBLASTP
17299791730866888chemotaxis MotA proteinQuickGO ontologyBLASTP
173086317321641302chemotaxis MotB proteinQuickGO ontologyBLASTP
173217517343462172chemotaxis protein CheAQuickGO ontologyBLASTP
17345091735006498chemotaxis protein CheWQuickGO ontologyBLASTP
173529817365331236hypothetical proteinBLASTP
17365461736923378YjgF-family lipoproteinQuickGO ontologyBLASTP
17369201737906987putative L-xylulose-5-phosphate 3-epimeraseQuickGO ontologyBLASTP
17380841738761678putative DNA-binding proteinQuickGO ontologyBLASTP