Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:2263347 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
22633472264039693transcriptional activatorQuickGO ontologyBLASTP
226404522654361392putative two-component system sensor proteinQuickGO ontologyBLASTP
22657132266135423putative decarboxylaseQuickGO ontologyBLASTP
22661902266660471hypothetical proteinBLASTP
22666652266793129hypothetical proteinBLASTP
226687322679461074hypothetical proteinBLASTP
22687372269642906hypothetical proteinBLASTP
22696482270580933hypothetical proteinBLASTP
22705672271517951hypothetical proteinBLASTP
22718582272538681putative dehydrogenaseQuickGO ontologyBLASTP
22726432273302660hypothetical proteinBLASTP
22734372274075639putative sugar-phosphate isomeraseQuickGO ontologyBLASTP
227432222764332112hypothetical proteinBLASTP
227701122791732163hypothetical proteinBLASTP
227929322805011209putative transposaseQuickGO ontologyBLASTP
228062022822781659hypothetical proteinBLASTP
22824482282912465hypothetical proteinBLASTP