Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:3790750 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
379075037921321383hypothetical proteinBLASTP
37922653792495231hypothetical proteinBLASTP
37930513793209159hypothetical proteinBLASTP
37932063793517312hypothetical proteinBLASTP
37935143793717204hypothetical proteinBLASTP
37941683795100933LysR-family regulatory proteinQuickGO ontologyBLASTP
37952623795978717hypothetical proteinBLASTP
37962383796540303hypothetical proteinBLASTP
37967553797159405putative translational inhibitor proteinQuickGO ontologyBLASTP
37974443797824381putative translational inhibitor proteinQuickGO ontologyBLASTP
37978403798466627hypothetical proteinBLASTP
37986003799046447hypothetical proteinBLASTP
380049338017251233putative aminotransferaseQuickGO ontologyBLASTP
38024913802691201hypothetical proteinBLASTP
38026883803023336hypothetical proteinBLASTP
380303338040821050putative HlyD family secretion proteinQuickGO ontologyBLASTP
380406638059671902hypothetical proteinBLASTP
380597238074981527hypothetical proteinBLASTP
380756238097452184putative glycosyl hydrolaseQuickGO ontologyBLASTP