Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:809943 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
809009809959951putative siderophore biosynthesis protein IucBQuickGO ontologyBLASTP
8099438110131071Aerobactin siderophore biosynthesis proteiniucAQuickGO ontologyBLASTP
811106811714609Aerobactin siderophore biosynthesis proteiniucAQuickGO ontologyBLASTP
8118548130771224hypothetical proteinBLASTP
813025813219195hypothetical proteinBLASTP
81318281327796hypothetical protein
813367814200834hypothetical proteinBLASTP
814257814376120hypothetical protein
8145778159531377hypothetical proteinBLASTP
816515817258744quorum-sensing transcriptional regulatorQuickGO ontologyBLASTP
817239817889651N-3-oxooctanoyl-L-homoserine lactone synthaseN-3-oxohexanoyl-L-homoserine lactone synthaseQuickGO ontologyBLASTP
819059819709651hypothetical proteinBLASTP
819834819959126hypothetical proteinBLASTP
820160820555396putative lipoproteinQuickGO ontologyBLASTP
820623820886264insertion element proteinQuickGO ontologyBLASTP
821060821431372hypothetical proteinBLASTP
821447821575129hypothetical proteinBLASTP
822831823331501hypothetical proteinBLASTP
8233748249181545hypothetical proteinBLASTP
8249308262821353hypothetical proteinBLASTP
826279826965687hypothetical proteinBLASTP
8269658287011737putative OmpA-family membrane proteinQuickGO ontologyBLASTP
828705829196492hypothetical proteinBLASTP
8296148322622649Clp ATPaseQuickGO ontologyBLASTP
8322598346072349hypothetical proteinBLASTP
8346228368442223hypothetical proteinBLASTP
836955837344390hypothetical proteinBLASTP
837771838046276insertion sequence proteinQuickGO ontologyBLASTP
838100838435336Insertion sequence proteinQuickGO ontologyBLASTP
838967839602636hypothetical proteinBLASTP
8396188419152298putative kinaseQuickGO ontologyBLASTP
841902842669768hypothetical proteinBLASTP