Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:2586729 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
258672925901513423hypothetical proteinBLASTP
259014825913801233hypothetical proteinBLASTP
25922102592383174transposaseQuickGO ontologyBLASTP
25924922592812321transposaseQuickGO ontologyBLASTP
25929432593080138transposaseQuickGO ontologyBLASTP
25933262593493168hypothetical protein
25935452594015471hypothetical proteinBLASTP
25940922594193102hypothetical proteinBLASTP
259418825963712184hypothetical proteinBLASTP
25963872596647261ABC-type multidrugproteinlipid transportsystem ATPase componentQuickGO ontologyBLASTP
25968012597574774hypothetical proteinBLASTP
259757125998712301putative kinaseQuickGO ontologyBLASTP
259988726022352349hypothetical proteinBLASTP
260223826048802643ClpB proteinQuickGO ontologyBLASTP
26052682605759492hypothetical proteinBLASTP
260576326074991737hypothetical proteinBLASTP
26074992608185687hypothetical proteinBLASTP
260818226095341353hypothetical proteinBLASTP
260954626110841539hypothetical proteinBLASTP
26111332611633501hypothetical proteinBLASTP
26126222613470849putative acyl transferaseQuickGO ontologyBLASTP
26135692613817249putative acyl carrier proteinQuickGO ontologyBLASTP
26138552614295441hypothetical proteinBLASTP
26142882614407120hypothetical proteinBLASTP
26143822615170789putative short chain dehydrogenaseQuickGO ontologyBLASTP
261663926178771239putative hydroxymethylglutaryl-coenzyme A synthaseQuickGO ontologyBLASTP
26178932618639747putative beta-ketoacyl-acyl-carrier-protein reductaseQuickGO ontologyBLASTP
261863226199151284putative beta-ketoacyl-acyl-carrier-protein synthaseQuickGO ontologyBLASTP
261990526204295253R-hydroxymyristoyl-ACP dehydrataseQuickGO ontologyBLASTP