Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:1571305 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
157130515724321128hypothetical proteinBLASTP
15727521573255504Fe-binding and storage proteinQuickGO ontologyBLASTP
15743121574809498putative N-acetyltransferaseQuickGO ontologyBLASTP
15748251575712888threonine and homoserine efflux systemQuickGO ontologyBLASTP
15757371575841105hypothetical protein
15761171576641525putative outer membrane proteinQuickGO ontologyBLASTP
15769571577895939Cobalt-zinc-cadmium resistance proteinQuickGO ontologyBLASTP
15781331578675543hypothetical proteinBLASTP
15788711579539669hypothetical proteinBLASTP
158012215813481227putative zinc-binding dehydrogenaseQuickGO ontologyBLASTP
15815231582440918sugar binding proteinQuickGO ontologyBLASTP
158248015839701491putative sugar transport system ATP-binding proteinQuickGO ontologyBLASTP
15839671584959993putative sugar transport system permeaseQuickGO ontologyBLASTP
158509215860961005putative LacI-family transcriptional regulatorQuickGO ontologyBLASTP
15863431587284942LysR family transcriptional regulatorQuickGO ontologyBLASTP
158738715884721086tartrate dehydrogenaseQuickGO ontologyBLASTP
15885411588723183hypothetical proteinBLASTP
158908915907351647putative BCCT-family transporterQuickGO ontologyBLASTP
15920011592966966putative dioxygenase subunit betaQuickGO ontologyBLASTP
159361915953071689putative hemolysin activator proteinQuickGO ontologyBLASTP
159531915974302112putative hemolysinQuickGO ontologyBLASTP
159741116030595649putative adhesinhemolysin precursorQuickGO ontologyBLASTP
16030611603570510hypothetical proteinBLASTP
16038151604066252hypothetical proteinBLASTP
160473016067632034hypothetical proteinBLASTP
16067731606970198hypothetical proteinBLASTP
16071731607340168hypothetical proteinBLASTP
16074821607886405hypothetical proteinBLASTP
16078951608038144hypothetical proteinBLASTP
16079861608438453hypothetical proteinBLASTP
16083231608670348hypothetical proteinBLASTP
16087111609241531hypothetical proteinBLASTP
160950716105861080putative mannitol transport ATP-binding proteinQuickGO ontologyBLASTP