Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:3375463 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
33754633375972510transposaseQuickGO ontologyBLASTP
3376087337618296hypothetical protein
337618433774431260gamma-glutamylphosphate reductaseQuickGO ontologyBLASTP
337745333785561104gamma-glutamyl kinaseQuickGO ontologyBLASTP
33787333379134402DNA-binding transcriptional regulatorQuickGO ontologyBLASTP
337919433804411248fermentationrespiration switch proteinQuickGO ontologyBLASTP
33805683381026459guanine-xanthine phosphoribosyltransferaseQuickGO ontologyBLASTP
33810233381124102hypothetical protein
33814533381758306hypothetical proteinBLASTP
338195533835591605putative carbohydrate-binding proteinQuickGO ontologyBLASTP
33836943384203510transposaseQuickGO ontologyBLASTP
33847293385640912putative LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
338751533889751461aminoacyl-histidine dipeptidaseQuickGO ontologyBLASTP
3388993338908593hypothetical protein
338908933901471059DNA polymerase IVQuickGO ontologyBLASTP
33905033391450948hypothetical proteinBLASTP
33916943391921228hypothetical proteinBLASTP
339193433929561023putative thiamine biosynthesis lipoproteinQuickGO ontologyBLASTP
339299733942201224Na-translocating NADH-quinone reductase subunit FQuickGO ontologyBLASTP
33942363394832597Na-translocating NADH-quinone reductase subunit EQuickGO ontologyBLASTP
33948393395468630Na-translocating NADH-quinone reductase subunit DQuickGO ontologyBLASTP
33954613396261801Na-translocating NADH-quinone reductase subunit CQuickGO ontologyBLASTP
339625133974921242NADH-ubiquinone oxidoreductase subunit BQuickGO ontologyBLASTP