Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:2557476 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
255747625586421167hypothetical proteinBLASTP
25586972559359663GTP cyclohydrolase IQuickGO ontologyBLASTP
255954325606941152hypothetical proteinBLASTP
25608302561699870putative LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
256197325631121140Alcohol dehydrogenase class IIIGlutathione-dependent formaldehyde dehydrogenaseQuickGO ontologyBLASTP
25631332563975843putative esteraseQuickGO ontologyBLASTP
25642442564444201hypothetical proteinBLASTP
256452825668882361hypothetical proteinBLASTP
256689025681521263hypothetical proteinBLASTP
25681542568822669ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
256883225701421311putative heme-binding proteinQuickGO ontologyBLASTP
257067725719511275molybdopterin biosynthesis proteinQuickGO ontologyBLASTP
25719532572723771molybdopterin synthase sulfurylaseQuickGO ontologyBLASTP
257285925740671209putative transposaseQuickGO ontologyBLASTP
25741112574764654hypothetical proteinBLASTP
257499225765871596ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
25772702577893624hypothetical proteinBLASTP
257810525794721368hypothetical proteinBLASTP
25794972579949453hypothetical proteinBLASTP
25799492580530582putative lipoproteinQuickGO ontologyBLASTP
258050525815901086hypothetical proteinBLASTP
258155425833171764hypothetical proteinBLASTP