Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:3240379 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
32403793240618240hypothetical proteinBLASTP
324265832438721215putative membrane efflux proteinQuickGO ontologyBLASTP
324410732457981692putative transporter with NADP-binding Rossmann-fold domainQuickGO ontologyBLASTP
324589532471991305inosine-guanosine kinaseQuickGO ontologyBLASTP
324740332485541152O-antigen chain length determinantQuickGO ontologyBLASTP
324860232499751374phosphomannomutaseQuickGO ontologyBLASTP
32499803250723744putative glycosyltransferaseQuickGO ontologyBLASTP
325072632521321407mannose-1-phosphate guanylyltransferaseQuickGO ontologyBLASTP
32523263253291966GDP-L-fucose synthetase Colanic acidbiosynthesis protein wcaGQuickGO ontologyBLASTP
325443532554481014putative mannosyltransferaseQuickGO ontologyBLASTP
32556973256629933O-unit polymerase-like proteinQuickGO ontologyBLASTP
325691532580571143putative mannosyltransferaseQuickGO ontologyBLASTP
32584373259150714putative glycosyltransferaseQuickGO ontologyBLASTP
325916132605041344putative O-unit flippaseQuickGO ontologyBLASTP
326057832618611284putative O-antigen synthesis protein WbyHQuickGO ontologyBLASTP
32618623262719858paratose synthaseQuickGO ontologyBLASTP
326275632640691314putative CDP-4-keto-6-deoxy-D-glucose-3-dehydrataseQuickGO ontologyBLASTP
326408732651601074UDP-glucose 4-epimeraseQuickGO ontologyBLASTP
32651653265938774glucose-1-phosphate cytidylyltransferaseQuickGO ontologyBLASTP
32659763266602627Na-translocating NADH-quinone reductase subunit FQuickGO ontologyBLASTP
32666503266964315CDP-6-deoxy-delta-34-glucoseen reductaseQuickGO ontologyBLASTP
32675623268524963ferrochelataseQuickGO ontologyBLASTP
32686143269258645adenylate kinaseQuickGO ontologyBLASTP
326948532713591875molecular chaperone HSP90 familyQuickGO ontologyBLASTP
32713783271536159hypothetical proteinBLASTP
32715513272156606gap repair proteinQuickGO ontologyBLASTP
32721563272488333hypothetical proteinBLASTP
327254432745201977Holliday junction DNA helicase RuvBQuickGO ontologyBLASTP
32749643275068105hypothetical protein
32759773276357381hypothetical proteinBLASTP