Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:1136000 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
11360811136401321putative addiction module killer proteinQuickGO ontologyBLASTP
11364011136721321putative DNA-binding prophage proteinQuickGO ontologyBLASTP
11367181136819102hypothetical protein
11368291137023195hypothetical proteinBLASTP
113707011381581089putative regulatory prophage proteinQuickGO ontologyBLASTP
11381551139114960putative prophage DNA primaseQuickGO ontologyBLASTP
11391071139649543putative prophage proteinQuickGO ontologyBLASTP
11396491139849201DNA-binding proteinQuickGO ontologyBLASTP
11398421140738897putative DNA-binding prophage proteinQuickGO ontologyBLASTP
11407511141041291hypothetical proteinBLASTP
11415371141764228hypothetical proteinBLASTP
114192611435961671hypothetical proteinBLASTP
114364711447351089hypothetical proteinBLASTP
114481411460131200putative prophage integraseQuickGO ontologyBLASTP
11462371146746510transposaseQuickGO ontologyBLASTP
11473301147812483trans-translation proteinQuickGO ontologyBLASTP
11479731148407435hypothetical proteinBLASTP
11484001148684285hypothetical proteinBLASTP
11488341149175342Outer membrane lipoprotein OmlAQuickGO ontologyBLASTP
114928911509501662recombination and repair proteinQuickGO ontologyBLASTP
11510371151918882ATP-NAD kinaseQuickGO ontologyBLASTP
11520421152620579heat shock proteinQuickGO ontologyBLASTP
115272811540081281citrate synthase GltAQuickGO ontologyBLASTP
11548771154990114hypothetical protein
11551011155448348succinate dehydrogenase membrane subunit binds cytochrome b556QuickGO ontologyBLASTP
115544911572151767succinate dehydrogenase flavoprotein subunitQuickGO ontologyBLASTP
11572651157981717succinate dehydrogenase FeS subunitQuickGO ontologyBLASTP
1158337116114428082-oxoglutarate decarboxylaseQuickGO ontologyBLASTP