Pre_GI Gene

Some Help

Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:1000342 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
99932310003451023transposaseQuickGO ontologyBLASTP
10003421001124783transposaseQuickGO ontologyBLASTP
100146910045823114hypothetical proteinBLASTP
100465210068382187hypothetical proteinBLASTP
10069531007903951hypothetical proteinBLASTP
10079251008119195hypothetical proteinBLASTP
10085061008694189hypothetical proteinBLASTP
10089071009014108hypothetical protein
10091901009945756putative carbonic anhydraseQuickGO ontologyBLASTP
10106881011104417hypothetical proteinBLASTP
10111721011675504general secretion pathway protein CQuickGO ontologyBLASTP
101175610136781923general secretion pathway protein DQuickGO ontologyBLASTP
101367510151861512general secretion pathway protein EQuickGO ontologyBLASTP
10151671015367201General secretion pathway protein F Type IIsecretory pathway component PulFQuickGO ontologyBLASTP
101532810163741047General secretion pathway protein FQuickGO ontologyBLASTP
10163941016831438general secretion pathway protein GQuickGO ontologyBLASTP
10168361017378543general secretion pathway protein HQuickGO ontologyBLASTP
10174161017760345general secretion pathway protein IQuickGO ontologyBLASTP
10177531018349597general secretion pathway protein JQuickGO ontologyBLASTP
10183581019314957general secretion pathway protein KQuickGO ontologyBLASTP
101929810204881191general secretion pathway protein LQuickGO ontologyBLASTP
10204851020946462hypothetical proteinBLASTP
10209721021814843prepilin peptidaseQuickGO ontologyBLASTP
10218661022171306putative lipoproteinQuickGO ontologyBLASTP
10224551023171717putative regulatory membrane proteinQuickGO ontologyBLASTP
10231681023569402hypothetical proteinBLASTP
10237721024203432methyl-accepting chemotaxis proteinQuickGO ontologyBLASTP
102424310254151173putative methyl-accepting chemotaxis proteinQuickGO ontologyBLASTP
10254011026036636hypothetical proteinBLASTP
10261491027036888hypothetical proteinBLASTP
10271431028051909LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
102842010295801161putative sugar transport proteinQuickGO ontologyBLASTP
10295771030518942DNA-binding transcriptional dual regulatorQuickGO ontologyBLASTP
103073310319951263diaminopimelate decarboxylaseQuickGO ontologyBLASTP
103199210330141023galactose operon repressorQuickGO ontologyBLASTP
103345910355852127biotin sulfoxide reductaseQuickGO ontologyBLASTP