Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:3821890 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
382189038241752286putative autotransporter proteinQuickGO ontologyBLASTP
38244433824607165putative adhesinhemolysin precursorQuickGO ontologyBLASTP
38246713825426756putative hemagglutininhemolysinQuickGO ontologyBLASTP
38254593825890432hypothetical proteinBLASTP
38258773826035159Rhs family proteinQuickGO ontologyBLASTP
38259713826198228hypothetical proteinBLASTP
38262533826402150putative adhesinhemolysin precursorQuickGO ontologyBLASTP
38266943827353660putative adhesinhemolysin precursorQuickGO ontologyBLASTP
382735538365829228putative adhesinhemolysin precursorQuickGO ontologyBLASTP
383662738383151689putative hemolysin activator proteinQuickGO ontologyBLASTP
38390303839668639putative tellurium resistance proteinQuickGO ontologyBLASTP
38397013840342642putative tellurium resistance proteinQuickGO ontologyBLASTP
38403443840982639hypothetical proteinBLASTP
38410843842067984hypothetical proteinBLASTP
384212338438561734hypothetical proteinBLASTP
384388838453871500putative kinase proteinQuickGO ontologyBLASTP