Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:1346685 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
13458201346695876sulfate transport system permease CysWQuickGO ontologyBLASTP
134668513477761092sulfatethiosulfate transporter subunit ATP-binding component of ABC superfamilyQuickGO ontologyBLASTP
13479471348825879cysteine synthase BQuickGO ontologyBLASTP
134907013503021233hypothetical proteinBLASTP
13506821351389708putative two-component response regulatorQuickGO ontologyBLASTP
135138613529301545putative two-component sensor histidine kinaseQuickGO ontologyBLASTP
13530211353182162hypothetical proteinBLASTP
135316313544761314hypothetical proteinBLASTP
135528913564701182putative aminotransferaseQuickGO ontologyBLASTP
13565041356695192hypothetical proteinBLASTP
135671613577231008hypothetical proteinBLASTP
13578661358063198hypothetical proteinBLASTP
135806013595201461putative permeaseQuickGO ontologyBLASTP
135958013612261647soluble pyridine nucleotide transhydrogenaseQuickGO ontologyBLASTP
136148113635172037ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
136352113647261206putative HlyD family secretion proteinQuickGO ontologyBLASTP