Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:3982020 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
398202039832041185sodium-proton antiporterQuickGO ontologyBLASTP
398344739845861140chaperone Hsp40 co-chaperone with DnaKQuickGO ontologyBLASTP
398469839866081911chaperone protein DnaKQuickGO ontologyBLASTP
39869823987593612inner membrane protein associated with acetate transportQuickGO ontologyBLASTP
398788239903292448hypothetical proteinBLASTP
399039939917871389putative transport proteinQuickGO ontologyBLASTP
39919153992502588putative molybdochelataseQuickGO ontologyBLASTP
39925883992746159hypothetical proteinBLASTP
39927903993743954transaldolase BQuickGO ontologyBLASTP
39938103993992183hypothetical proteinBLASTP
39942753995051777hypothetical proteinBLASTP
399586839971571290threonine synthaseQuickGO ontologyBLASTP
39971613998090930homoserine kinaseQuickGO ontologyBLASTP