Pre_GI Gene

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Host: NC_017265 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017265:4265659 Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
426565942678572199putative Rhs accessory genetic elementQuickGO ontologyBLASTP
42678794268055177hypothetical proteinBLASTP
42682184268625408transcriptional regulatorQuickGO ontologyBLASTP
42687074268931225hypothetical proteinBLASTP
42690074269198192hypothetical proteinBLASTP
42692484269733486hypothetical proteinBLASTP
42697354270043309Rhs-family proteinQuickGO ontologyBLASTP
42701084271106999Rhs-family proteinQuickGO ontologyBLASTP
42739924274450459hypothetical proteinBLASTP
427445642768582403putative Rhs accessory genetic elementQuickGO ontologyBLASTP
42768804277413534hypothetical proteinBLASTP
42774104278192783hypothetical proteinBLASTP
427831742818503534hypothetical proteinBLASTP
428188242832701389hypothetical proteinBLASTP
42832764283962687hypothetical proteinBLASTP
42839594284756798hypothetical proteinBLASTP
428475342873562604ClpB proteinQuickGO ontologyBLASTP