Pre_GI: BLASTP Hits

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Query: NC_009525:2802987:2801248 Mycobacterium tuberculosis H37Ra, complete genome

Start: 2801248, End: 2802990, Length: 1743

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (H37Ra; ATCC 25177) is an avirulent strain derived from its virulent parent strain H37 (isolated from a 19 year-old male patient with chronic pulmonary tuberculosis by Edward R. Baldwin in 1905). Causative agent of tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_000962:2791019:2789280278928027910221743Mycobacterium tuberculosis H37Rv, complete genomePOSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONNAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERINE PHOSPHOHYDROLASE) 0953
NC_012207:2747599:2745860274586027476021743Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative transmembrane phospholipid biosynthesis enzyme0948
NC_002945:2757821:2756082275608227578241743Mycobacterium bovis AF2122/97, complete genomebifunctionnal putative L-3-phosphoserine phosphatase/1-acyl-SN-glycerol-3-phosphate acyltransferase0948
NC_008769:2754828:2753089275308927548311743Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative transmembrane phospholipid biosynthesis bifunctionnal enzyme plsC: putative l-3-phosphoserine phosphatase + 1-ACYL-SN-GLYCEROL-3-PHOSPHATE AC0948
NC_002677:1462233:1484289148428914860281740Mycobacterium leprae TN, complete genomepossible transferase0803
NC_011896:1462258:1484313148431314860521740Mycobacterium leprae Br4923, complete genomeputative transferase0803
NC_016906:3286384:3305667330566733071541488Gordonia polyisoprenivorans VH2 chromosome, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase4e-82306
NC_014624:3810163:381462738146273815454828Eubacterium limosum KIST612 chromosome, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase2e-24114
NC_010520:496500:509756509756510478723Clostridium botulinum A3 str. Loch Maree, complete genomeputative 1-acyl-sn-glycerol-3-phosphate acyltransferase3e-20100
NC_015425:2024154:202817420281742028842669Clostridium botulinum BKT015925 chromosome, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase5e-2099.8
NC_005125:3420270:342027034202703421040771Gloeobacter violaceus PCC 7421, complete genomehypothetical protein7e-2099.4
NC_009698:467500:480686480686481408723Clostridium botulinum A str. Hall chromosome, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase1e-1998.6
NC_009697:444801:460298460298461020723Clostridium botulinum A str. ATCC 19397 chromosome, complete1-acyl-sn-glycerol-3-phosphate acyltransferase1e-1998.6
NC_009495:482500:495523495523496245723Clostridium botulinum A str. ATCC 3502 chromosome, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase1e-1998.6
NC_012563:519037:534717534717535439723Clostridium botulinum A2 str. Kyoto, complete genomeputative 1-acyl-sn-glycerol-3-phosphate acyltransferase2e-1998.2
NC_012658:482313:497519497519498241723Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative 1-acyl-sn-glycerol-3-phosphate acyltransferase1e-1998.2
NC_017297:490922:506958506958507680723Clostridium botulinum F str. 230613 chromosome, complete genomeputative 1-acyl-sn-glycerol-3-phosphate acyltransferase2e-1997.8
NC_009699:490652:506688506688507410723Clostridium botulinum F str. Langeland chromosome, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase2e-1997.8
NC_014328:711842:725500725500726225726Clostridium ljungdahlii ATCC 49587 chromosome, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase2e-1997.8
NC_010516:514000:526978526978527700723Clostridium botulinum B1 str. Okra, complete genomeputative 1-acyl-sn-glycerol-3-phosphate acyltransferase2e-1997.8
NC_002944:4446083:445411044541104455021912Mycobacterium avium subsp. paratuberculosis K-10, complete genomeSerB4e-1996.7
NC_010723:3499291:351884435188443519563720Clostridium botulinum E3 str. Alaska E43, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase6e-1996.3
NC_011837:950000:976040976040976765726Clostridium kluyveri NBRC 12016, complete genomehypothetical protein3e-1790.5
NC_013939:1535071:153437715343771535081705Deferribacter desulfuricans SSM1, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase8e-1789.4
NC_004129:2034500:204014020401402040862723Pseudomonas fluorescens Pf-5, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase1e-1689
NC_003030:1097625:111036311103631111088726Clostridium acetobutylicum ATCC 824, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase2e-1687.8
NC_015687:1097447:111018511101851110910726Clostridium acetobutylicum DSM 1731 chromosome, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase2e-1687.8
NC_007760:1806136:183295118329511833715765Anaeromyxobacter dehalogenans 2CP-C, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase2e-1584.7
NC_003228:3455405:346751734675173468365849Bacteroides fragilis NCTC 9343, complete genomeputative phospholipids biosynthesis-related protein5e-1583.2
NC_016776:3485688:349921034992103500058849Bacteroides fragilis 638R, complete genomeputative phospholipids biosynthesis-related protein4e-1583.2
NC_014393:3425694:343159434315943432310717Clostridium cellulovorans 743B chromosome, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase7e-1582.8
NC_011146:4505821:451073345107334511428696Geobacter bemidjiensis Bem, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase2e-1481.6
NC_016830:4809210:482536148253614826083723Pseudomonas fluorescens F113 chromosome, complete genomeprotein PatB2e-1481.3
NC_012806:105133:121111121111121863753Mycoplasma conjunctivae, complete genome1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE4e-1480.1
NC_014391:421547:436794436794437600807Micromonospora aurantiaca ATCC 27029 chromosome, complete genomeHAD-superfamily hydrolase5e-1480.1
NC_003155:5616000:562228656222865623119834Streptomyces avermitilis MA-4680, complete genomemorphological differentiation-associated protein5e-1479.7
NC_021182:3409199:340919934091993409921723Clostridium pasteurianum BC1, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase1e-1379
NC_016582:7101701:710170171017017102537837Streptomyces bingchenggensis BCW-1 chromosome, complete genomemorphological differentiation-associated protein4e-1377
NC_016114:3938721:394742439474243948263840Streptomyces flavogriseus ATCC 33331 chromosome, complete genomeHAD-superfamily hydrolase8e-1375.9
NC_005061:65861:711827118271916735Candidatus Blochmannia floridanus, complete genome1-acyl-glycerol-3-phosphate acyltransferase9e-1375.9
NC_009749:77583:818188181882468651Francisella tularensis subsp. holarctica FTA, complete genomeacetyltransferase protein1e-1275.5
NC_015577:2508027:253193725319372532686750Treponema azotonutricium ZAS-9 chromosome, complete genome1-acyl-sn-glycerol-3-phosphate acetyltransferase1e-1275.5
NC_008278:4023918:4031582403158240340172436Frankia alni ACN14a, complete genomePutative fatty acyl coA reductase1e-1275.1
NC_016937:1850382:185038218503821851032651Francisella tularensis subsp. tularensis TI0902 chromosome,1-acylglycerol-3-phosphate O-acyltransferase2e-1275.1
NC_009921:4948500:4955996495599649583592364Frankia sp. EAN1pec, complete genomeHAD-superfamily subfamily IB hydrolase, TIGR014902e-1274.7
NC_013192:1765981:178726117872611788013753Leptotrichia buccalis DSM 1135, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase2e-1274.7
NC_009257:5615:215532155322293741Francisella tularensis subsp. tularensis WY96-3418 chromosome,acetyltransferase protein2e-1274.3
NC_008245:1845525:185031218503121851052741Francisella tularensis subsp. tularensis FSC 198, complete genomeAcetyltransferase protein2e-1274.3
NC_014935:1511835:151874715187471519457711Nitratifractor saLSUginis DSM 16511 chromosome, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase4e-1273.6
NC_004557:558500:571575571575572303729Clostridium tetani E88, complete genomeputative 1-acyl-sn-glycerol-3-phosphate acyltransferase5e-1273.2
NC_011768:3854455:385588038558803856542663Desulfatibacillum alkenivorans AK-01, complete genomeHAD-superfamily subfamily IB hydrolase, TIGR014901e-1171.6
NC_012660:5121219:513624951362495136971723Pseudomonas fluorescens SBW25 chromosome, complete genomeputative acyltransferase2e-1171.2
NC_009512:5632591:568192156819215682577657Pseudomonas putida F1, complete genomeHAD-superfamily subfamily IB hydrolase, TIGR014903e-1170.9
NC_013960:3379515:338517133851713385836666Nitrosococcus halophilus Nc4 chromosome, complete genomeHAD-superfamily subfamily IB hydrolase, TIGR014903e-1170.5
NC_013169:1410384:141134714113471412141795Kytococcus sedentarius DSM 20547, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase4e-1170.1
NC_020209:4768500:480218348021834802953771Pseudomonas poae RE*1-1-14, complete genomephospholipid/glycerol acyltransferase5e-1170.1
NC_011979:589874:593387593387594106720Geobacter sp. FRC-32, complete genomeHAD-superfamily subfamily IB hydrolase, TIGR014908e-1169.3
NC_007777:2638580:2654498265449826569572460Frankia sp. CcI3, complete genomeHAD-superfamily subfamily IB, PSPase-like1e-1068.9
NC_015656:2795784:2815207281520728175822376Frankia symbiont of Datisca glomerata chromosome, complete genomeHAD-superfamily hydrolase1e-1068.6
NC_007614:620500:632769632769633620852Nitrosospira multiformis ATCC 25196 chromosome 1, completePhospholipid/glycerol acyltransferase3e-1067.4
NC_014166:401815:402995402995403684690Arcobacter nitrofigilis DSM 7299 chromosome, complete genomephospholipid/glycerol acyltransferase4e-1067
NC_010694:2716348:272023627202362720886651Erwinia tasmaniensis, complete genomeHAD-superfamily hydrolase, subfamily IB5e-1066.6
NC_011761:684969:684969684969685661693Acidithiobacillus ferrooxidans ATCC 23270 chromosome, completeHAD-superfamily hydrolase8e-1065.9
NC_011206:863987:863987863987864679693Acidithiobacillus ferrooxidans ATCC 53993, complete genomeHAD-superfamily subfamily IB hydrolase, TIGR014908e-1065.9
NC_015677:2939301:296037829603782961055678Ramlibacter tataouinensis TTB310 chromosome, complete genomehypothetical protein2e-0964.7
NC_002516:6255854:701870187791774Pseudomonas aeruginosa PAO1, complete genomelysophosphatidic acid acyltransferase, LptA2e-0964.7
NC_009257:5615:207872078721539753Francisella tularensis subsp. tularensis WY96-3418 chromosome,acetyltransferase protein3e-0964.3
NC_008245:1845525:185106618510661851818753Francisella tularensis subsp. tularensis FSC 198, complete genomeAcetyltransferase protein3e-0963.9
NC_016937:1850382:185113618511361851888753Francisella tularensis subsp. tularensis TI0902 chromosome,HdtS protein3e-0963.9
NC_008783:29972:493214932150127807Bartonella bacilliformis KC583, complete genomeacyltransferase family protein4e-0963.5
NC_014376:6296:171491714917862714Clostridium saccharolyticum WM1 chromosome, complete genomephospholipid/glycerol acyltransferase4e-0963.5
NC_018080:1730534:174928317492831749933651Pseudomonas aeruginosa DK2 chromosome, complete genomehypothetical protein5e-0963.2
NC_011661:1175743:117729911772991177934636Dictyoglomus turgidum DSM 6724, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase7e-0962.8
NC_015687:279641:295413295413296156744Clostridium acetobutylicum DSM 1731 chromosome, complete genomephosphoserine phosphatase-like protein7e-0962.8
NC_003030:279643:295415295415296158744Clostridium acetobutylicum ATCC 824, complete genomePhosphoserine phosphatase related protein7e-0962.8
NC_017295:279633:295405295405296148744Clostridium acetobutylicum EA 2018 chromosome, complete genomePhosphoserine phosphatase related protein7e-0962.8
NC_009749:77583:825728257283276705Francisella tularensis subsp. holarctica FTA, complete genomeacetyltransferase protein7e-0962.8
NC_008369:82515:825158251583267753Francisella tularensis subsp. holarctica OSU18, complete genomeacyltransferase7e-0962.8
NC_009089:370555:370555370555371283729Clostridium difficile 630, complete genomeputative phosphoserine phosphatase9e-0962.4
NC_013316:371953:371953371953372681729Clostridium difficile R20291, complete genomeputative phosphoserine phosphatase9e-0962.4
NC_016616:1233555:125519712551971255940744Dechlorosoma suillum PS chromosome, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase9e-0962.4
NC_014722:2260489:228182122818212282702882Burkholderia rhizoxinica HKI 454, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase1e-0862.4
NC_014633:655693:673639673639674355717Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequenceHAD-superfamily hydrolase2e-0861.6
NC_016610:2605922:2608253260825326117503498Tannerella forsythia ATCC 43037 chromosome, complete genomeAcyltransferase2e-0861.6
NC_008789:942309:964198964198964881684Halorhodospira halophila SL1, complete genomeHAD-superfamily subfamily IB hydrolase, TIGR014902e-0861.2
NC_010793:1811401:183277718327771833541765Orientia tsutsugamushi str. Ikeda, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase3e-0860.8
NC_018080:4280401:430595043059504306603654Pseudomonas aeruginosa DK2 chromosome, complete genomehypothetical protein3e-0860.8
NC_006512:2789098:279357227935722794240669Idiomarina loihiensis L2TR, complete genomeProbable phosphoserine phosphatase, HAD-superfamily hydrolase3e-0860.5
NC_016612:443398:449628449628450278651Klebsiella oxytoca KCTC 1686 chromosome, complete genomeHAD superfamily hydrolase3e-0860.5
NC_008463:4389721:441518444151844415837654Pseudomonas aeruginosa UCBPP-PA14, complete genomePossible phosphoserine phosphatase5e-0860.1
NC_009488:186000:206775206775207539765Orientia tsutsugamushi str. Boryong, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase5e-0860.1
NC_011891:2088134:211006021100602110875816Anaeromyxobacter dehalogenans 2CP-1, complete genome1-acylglycerol-3-phosphate O-acyltransferase5e-0859.7
NC_016111:6175975:618444561844456185143699Streptomyces cattleya NRRL 8057, complete genomehypothetical protein7e-0859.3
NC_016148:1175999:118488911848891185539651Thermovirga lienii DSM 17291 chromosome, complete genomephospholipid/glycerol acyltransferase1e-0758.5
NC_016002:2037374:207892820789282079596669Pseudogulbenkiania sp. NH8B, complete genomeHAD family hydrolase2e-0758.2
NC_018645:4490957:449859944985994499342744Desulfobacula toluolica Tol2, complete genomephospholipid/glycerol acetyltransferase3e-0757.4
NC_011000:3409126:342847034284703429327858Burkholderia cenocepacia J2315 chromosome 1, complete sequenceputative 1-acyl-SN-glycerol-3-phosphate acyltransferase3e-0757.4
NC_008390:818571:821560821560822417858Burkholderia cepacia AMMD chromosome 1, complete sequencephospholipid/glycerol acyltransferase4e-0757
NC_016630:1385719:138969413896941390263570Filifactor alocis ATCC 35896 chromosome, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase4e-0757
NC_014655:3141144:316279131627913163534744Leadbetterella byssophila DSM 17132 chromosome, complete genomephospholipid/glycerol acyltransferase5e-0756.6
NC_010161:2548254:257007225700722570878807Bartonella tribocorum CIP 105476, complete genomehypothetical protein6e-0756.2
NC_002163:1354215:137205613720561372691636Campylobacter jejuni subsp. jejuni NCTC 11168, complete genomehypothetical protein6e-0756.2
NC_011283:4438500:443862944386294439294666Klebsiella pneumoniae 342 chromosome, complete genomeHAD-superfamily hydrolase1e-0655.5
NC_016778:1216739:124087712408771241659783Brucella canis HSK A52141 chromosome 1, complete sequence1-acyl-sn-glycerol-3-phosphate acyltransferase1e-0655.1
NC_003317:48375:723707237073272903Brucella melitensis 16M chromosome I, complete sequence1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE1e-0655.1
NC_016795:456110:480087480087480989903Brucella abortus A13334 chromosome 1, complete sequence1-acyl-sn-glycerol-3-phosphate acyltransferase1e-0655.1
NC_010084:2717443:273871127387112739568858Burkholderia multivorans ATCC 17616 chromosome 1, completephospholipid/glycerol acyltransferase2e-0654.7
NC_010804:782222:785205785205786062858Burkholderia multivorans ATCC 17616 chromosome 1, complete1-acyl-sn-glycerol-3-phosphate acyltransferase2e-0654.7
NC_007298:3764048:378887337888733789625753Dechloromonas aromatica RCB, complete genomePhospholipid/glycerol acyltransferase2e-0654.3
NC_007406:632436:653775653775654554780Nitrobacter winogradskyi Nb-255, complete genomephospholipid/glycerol acyltransferase3e-0654.3
NC_012731:1088321:110805311080531108718666Klebsiella pneumoniae NTUH-K2044 chromosome, complete genomefamily IB HAD-hydrolase5e-0653.5
NC_014117:442616:464061464061464771711Burkholderia sp. CCGE1002 chromosome chromosome 1, completephospholipid/glycerol acyltransferase5e-0653.5
NC_007951:570500:574477574477575163687Burkholderia xenovorans LB400 chromosome 1, complete sequenceHAD-superfamily subfamily IB hydrolase, hypothetical 24e-0653.5
NC_006156:17637:357023570236439738Borrelia garinii PBi chromosome linear, complete sequence1-acyl-sn-glycerol-3-phosphate acyltransferase6e-0653.1
NC_013851:3392644:339192933919293392693765Allochromatium vinosum DSM 180 chromosome, complete genomephospholipid/glycerol acyltransferase6e-0652.8
NC_014148:4037357:405090940509094051778870Planctomyces limnophilus DSM 3776 chromosome, complete genomephospholipid/glycerol acyltransferase8e-0652.8
NC_018012:1935500:1956937195693719597262790Thiocystis violascens DSM 198 chromosome, complete genome1-acyl-sn-glycerol-3-phosphate acyltransferase9e-0652.4
NC_007777:2459357:246182724618272462507681Frankia sp. CcI3, complete genomeHAD-superfamily subfamily IB, PSPase-like9e-0652.4