Pre_GI Gene

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Host: NC_012563 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012563:519037 Clostridium botulinum A2 str. Kyoto, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
5190375216372601clpB proteinQuickGO ontologyBLASTP
521927522655729glutamine amidotransferase CobBCobQ familyQuickGO ontologyBLASTP
5227135240741362UDP-N-acetylmuramyl tripeptide synthetase homologQuickGO ontologyBLASTP
524339525319981mannose-6-phosphate isomerase class IQuickGO ontologyBLASTP
5256685267831116putative lipoproteinQuickGO ontologyBLASTP
526891527745855putative undecaprenol kinaseQuickGO ontologyBLASTP
528155529656150216S ribosomal RNAQuickGO ontologyBLASTP
52979952987678tRNA-AlaQuickGO ontologyBLASTP
52988152995777tRNA-IleQuickGO ontology
531367531822456hypothetical proteinBLASTP
531896532552657hypothetical proteinBLASTP
5330645331801175S ribosomal RNAQuickGO ontologyBLASTP
53318853326477tRNA-AsnQuickGO ontologyBLASTP
533717534580864metallo-beta-lactamase family proteinQuickGO ontologyBLASTP
534717535439723putative 1-acyl-sn-glycerol-3-phosphate acyltransferaseQuickGO ontologyBLASTP
5361855375461362HMGL-related enzymeQuickGO ontologyBLASTP
5376905396151926aconitaseisopropylmalate dehydratase family proteinQuickGO ontologyBLASTP
539818540816999dehydrogenase isocitrateisopropylmalate familyQuickGO ontologyBLASTP
541066541848783polar amino acid uptake family ABC transporter PAAT family ATP-binding proteinQuickGO ontologyBLASTP
5423715441371767NaH antiporter family proteinQuickGO ontologyBLASTP
544164544379216hypothetical proteinBLASTP
544467544850384aspartate 1-decarboxylaseQuickGO ontologyBLASTP
544976545821846pantoate--beta-alanine ligaseQuickGO ontologyBLASTP