Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:490922 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
4909224935222601clpB proteinQuickGO ontologyBLASTP
494185494913729CobBCobQ family glutamine amidotransferaseQuickGO ontologyBLASTP
4949714962841314UDP-N-acetylmuramyl tripeptide synthetase-like proteinQuickGO ontologyBLASTP
496597497577981mannose-6-phosphate isomeraseQuickGO ontologyBLASTP
4979274990421116putative lipoproteinQuickGO ontologyBLASTP
499150500004855undecaprenyl-diphosphatase UppPQuickGO ontologyBLASTP
50205950213476tRNA-AlaQuickGO ontologyBLASTP
50550750558175tRNA-AsnQuickGO ontology
505958506821864metallo-beta-lactamase family proteinQuickGO ontologyBLASTP
506958507680723putative 1-acyl-sn-glycerol-3-phosphate acyltransferaseQuickGO ontologyBLASTP
5099165118411926aconitate hydrataseQuickGO ontologyBLASTP
511877512875999isocitrateisopropylmalate family dehydrogenaseQuickGO ontologyBLASTP
513123513908786polar amino acid uptake family ABC transporter PAAT family ATP-binding proteinQuickGO ontologyBLASTP
5144275161931767NaH antiporter family proteinQuickGO ontologyBLASTP
516220516435216hypothetical proteinBLASTP
516523516906384aspartate 1-decarboxylaseQuickGO ontologyBLASTP