Pre_GI Gene

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Host: NC_010161 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010161:2548254 Bartonella tribocorum CIP 105476, complete genome

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
25482542549219966hypothetical proteinBLASTP
25492322549573342hypothetical proteinBLASTP
254957025506191050hypothetical proteinBLASTP
255123125524361206hypothetical proteinBLASTP
255242925540061578phage proteinQuickGO ontologyBLASTP
255401925556411623phage proteinQuickGO ontologyBLASTP
25556342556215582phage proteinQuickGO ontologyBLASTP
25561782556534357hypothetical proteinBLASTP
25565312556845315hypothetical proteinBLASTP
25570462557387342hypothetical proteinBLASTP
25573802557667288hypothetical proteinBLASTP
25576642558245582hypothetical proteinBLASTP
25583322558739408hypothetical proteinBLASTP
25587462559363618hypothetical proteinBLASTP
25593862560009624hypothetical proteinBLASTP
25600022560274273hypothetical proteinBLASTP
25602712560540270hypothetical proteinBLASTP
256053725615681032bacteriophage DNA transposition protein BQuickGO ontologyBLASTP
256192625639051980transposase class IIIQuickGO ontologyBLASTP
25639022564360459hypothetical proteinBLASTP
25643572565265909chromosome partitioning protein parBQuickGO ontologyBLASTP
25652652565663399hypothetical proteinBLASTP
25658612566166306hypothetical proteinBLASTP
25663202566850531hypothetical proteinBLASTP
25681152568591477hypothetical proteinBLASTP
25690882569942855phosphomethylpyrimidine kinaseQuickGO ontologyBLASTP
25700722570878807hypothetical proteinBLASTP
25718452571958114hypothetical protein
257250325735941092penicillin-binding proteinQuickGO ontologyBLASTP
25743512574509159putative integraseQuickGO ontologyBLASTP
257455825756281071hypothetical proteinBLASTP