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Query: NC_010161:2548254:2554019 Bartonella tribocorum CIP 105476, complete genome

Start: 2554019, End: 2555641, Length: 1623

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010161:1324381:1330146133014613317681623Bartonella tribocorum CIP 105476, complete genomephage protein01112
NC_010161:1949637:1955843195584319574651623Bartonella tribocorum CIP 105476, complete genomephage protein01112
NC_010161:1501758:1507523150752315091451623Bartonella tribocorum CIP 105476, complete genomephage protein01112
NC_020301:853267:8680038680038696251623Bartonella vinsonii subsp. berkhoffii str. Winnie, complete genomephage protein0979
NC_002927:3827211:3854529385452938562111683Bordetella bronchiseptica RB50, complete genomehypothetical protein2e-122439
NC_011750:2009889:2016153201615320177481596Escherichia coli IAI39 chromosome, complete genomeputative phage-related protein9e-114410
NC_016002:2179969:2179969217996921815161548Pseudogulbenkiania sp. NH8B, complete genomeMu-like prophage FluMu protein gp281e-109397
NC_016002:1741109:1741618174161817431651548Pseudogulbenkiania sp. NH8B, complete genomeMu-like prophage FluMu protein gp281e-109397
NC_014972:2798670:2800232280023228017581527Desulfobulbus propionicus DSM 2032 chromosome, complete genomehypothetical protein2e-108393
NC_015424:1987964:1987964198796419895321569Aeromonas veronii B565 chromosome, complete genomeMu-like prophage FluMu protein gp283e-104379
NC_000907:1568867:1572524157252415740501527Haemophilus influenzae Rd KW20, complete genomehypothetical protein9e-104377
NC_002940:78392:8487184871864301560Haemophilus ducreyi 35000HP, complete genomeMu-like phage gp285e-99362
NC_014228:3282500:3294891329489132964411551Xenorhabdus nematophila ATCC 19061, complete genomeputative Mu-like prophage FluMu protein gp283e-96352
NC_007519:3326918:3339877333987733413491473Desulfovibrio alaskensis G20 chromosome, complete genomeportal protein4e-86319
NC_018604:305957:3170513170513185141464Brachyspira pilosicoli WesB complete genomehypothetical protein2e-72273
NC_017243:58000:642366423664904669Brachyspira intermedia PWS/A chromosome, complete genomeportal protein2e-32140
NC_017243:58000:650276502765701675Brachyspira intermedia PWS/A chromosome, complete genomehypothetical protein1e-22108