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Query: NC_010161:2548254:2557380 Bartonella tribocorum CIP 105476, complete genome

Start: 2557380, End: 2557667, Length: 288

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010161:1949637:195920419592041959491288Bartonella tribocorum CIP 105476, complete genomehypothetical protein6e-49192
NC_010161:1501758:151088315108831511170288Bartonella tribocorum CIP 105476, complete genomehypothetical protein6e-48189
NC_010161:1324381:133350613335061333793288Bartonella tribocorum CIP 105476, complete genomehypothetical protein6e-48189
NC_020301:853267:865991865991866263273Bartonella vinsonii subsp. berkhoffii str. Winnie, complete genomehypothetical protein9e-1992