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Query: NC_010161:2548254:2558746 Bartonella tribocorum CIP 105476, complete genome

Start: 2558746, End: 2559363, Length: 618

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010161:1949637:196057019605701961187618Bartonella tribocorum CIP 105476, complete genomehypothetical protein6e-116416
NC_010161:1501758:151224915122491512866618Bartonella tribocorum CIP 105476, complete genomehypothetical protein2e-87321
NC_010161:1324381:133487213348721335489618Bartonella tribocorum CIP 105476, complete genomehypothetical protein2e-87321
NC_020301:853267:864280864280864897618Bartonella vinsonii subsp. berkhoffii str. Winnie, complete genomehypothetical protein9e-79292
NC_011750:1978801:200253320025332003024492Escherichia coli IAI39 chromosome, complete genomehypothetical protein1e-1582.8
NC_002940:78392:811198111981583465Haemophilus ducreyi 35000HP, complete genomeMu-like phage E16 protein1e-0756.6
NC_017501:1352752:137239613723961372830435Neisseria meningitidis 8013, complete genomephage protein5e-0754.3
NC_014228:3282500:329003832900383290574537Xenorhabdus nematophila ATCC 19061, complete genomehypothetical protein1e-0653.1