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Query: NC_010161:2548254:2563902 Bartonella tribocorum CIP 105476, complete genome

Start: 2563902, End: 2564360, Length: 459

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010161:1949637:196572619657261966184459Bartonella tribocorum CIP 105476, complete genomehypothetical protein1e-83308
NC_020301:853267:859301859301859762462Bartonella vinsonii subsp. berkhoffii str. Winnie, complete genomehypothetical protein9e-80295
NC_020301:669000:695747695747696208462Bartonella vinsonii subsp. berkhoffii str. Winnie, complete genomehypothetical protein6e-77285
NC_010161:1324381:134000813400081340466459Bartonella tribocorum CIP 105476, complete genomehypothetical protein4e-76282
NC_010161:1501758:151738515173851517843459Bartonella tribocorum CIP 105476, complete genomehypothetical protein4e-76282
NC_011989:2549252:254879125487912549255465Agrobacterium vitis S4 chromosome 1, complete sequencehypothetical protein3e-42170