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Query: NC_010161:2548254:2565265 Bartonella tribocorum CIP 105476, complete genome

Start: 2565265, End: 2565663, Length: 399

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_020301:669000:694467694467694865399Bartonella vinsonii subsp. berkhoffii str. Winnie, complete genomehypothetical protein1e-55214
NC_020301:853267:858049858049858447399Bartonella vinsonii subsp. berkhoffii str. Winnie, complete genomehypothetical protein5e-54209
NC_010161:1949637:196704119670411967439399Bartonella tribocorum CIP 105476, complete genomehypothetical protein8e-54208
NC_010161:1324381:134147913414791341877399Bartonella tribocorum CIP 105476, complete genomehypothetical protein2e-53206
NC_010161:1501758:151885615188561519254399Bartonella tribocorum CIP 105476, complete genomehypothetical protein2e-53206
NC_011989:2549252:255010825501082550458351Agrobacterium vitis S4 chromosome 1, complete sequencehypothetical genomic island protein7e-1165.9