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Query: NC_010161:2548254:2566320 Bartonella tribocorum CIP 105476, complete genome

Start: 2566320, End: 2566850, Length: 531

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010161:1949637:196806919680691968620552Bartonella tribocorum CIP 105476, complete genomehypothetical protein1e-68258
NC_010161:1324381:134252113425211343051531Bartonella tribocorum CIP 105476, complete genomehypothetical protein9e-64242
NC_010161:1501758:151989815198981520428531Bartonella tribocorum CIP 105476, complete genomehypothetical protein9e-64242
NC_020301:853267:857051857051857413363Bartonella vinsonii subsp. berkhoffii str. Winnie, complete genomehypothetical protein4e-22103
NC_005956:1019788:102049510204951020779285Bartonella henselae str. Houston-1, complete genomehypothetical genomic island protein7e-2096.7
NC_011989:2549252:255180625518062552465660Agrobacterium vitis S4 chromosome 1, complete sequencetranscriptional regulator3e-0961.6
NC_005956:1455496:147318414731841473395212Bartonella henselae str. Houston-1, complete genome1e-0859.3
NC_015577:427752:445381445381445740360Treponema azotonutricium ZAS-9 chromosome, complete genomehelix-turn-helix domain-containing protein1e-0653.1
NC_005956:1019788:102078410207841020942159Bartonella henselae str. Houston-1, complete genome2e-0652
NC_011296:281930:2841652841652851931029Thermodesulfovibrio yellowstonii DSM 11347, complete genomeexonuclease sbcc, putative4e-0650.8