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Query: NC_010161:2548254:2559386 Bartonella tribocorum CIP 105476, complete genome

Start: 2559386, End: 2560009, Length: 624

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010161:1949637:196121019612101961833624Bartonella tribocorum CIP 105476, complete genomehypothetical protein2e-119427
NC_020301:853267:863647863647864270624Bartonella vinsonii subsp. berkhoffii str. Winnie, complete genomehypothetical protein7e-112402
NC_010161:1501758:151287715128771513500624Bartonella tribocorum CIP 105476, complete genomehypothetical protein1e-110398
NC_010161:1324381:133550013355001336123624Bartonella tribocorum CIP 105476, complete genomehypothetical protein1e-110398
NC_014972:2798670:281170728117072812492786Desulfobulbus propionicus DSM 2032 chromosome, complete genomehypothetical protein6e-41167
NC_002927:3827211:386680438668043867424621Bordetella bronchiseptica RB50, complete genomehypothetical protein3e-39161
NC_018604:305957:325195325195325809615Brachyspira pilosicoli WesB complete genomeputative sulfate transport protein CysZ5e-38157
NC_014228:3282500:328831632883163288945630Xenorhabdus nematophila ATCC 19061, complete genomehypothetical protein9e-38156
NC_017243:58000:717907179072407618Brachyspira intermedia PWS/A chromosome, complete genomesulfate transport protein CysZ4e-36150
NC_012691:779826:799673799673800290618Tolumonas auensis DSM 9187, complete genomehypothetical protein2e-34145
NS_000195:526983:537468537468538130663Candidatus Cloacamonas acidaminovoranshypothetical protein2e-32139
NS_000195:219785:259587259587260249663Candidatus Cloacamonas acidaminovoranshypothetical protein4e-32137
NC_009850:1651410:168326816832681683924657Arcobacter butzleri RM4018, complete genomephage uncharacterized protein6e-22103
NC_017192:1885457:189584318958431896685843Arcobacter sp. L, complete genomehypothetical protein7e-1167.4
NC_015914:61306:964649646497093630Cyclobacterium marinum DSM 745 chromosome, complete genomehypothetical protein9e-0960.1