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Query: NC_010161:2548254:2548254 Bartonella tribocorum CIP 105476, complete genome

Start: 2548254, End: 2549219, Length: 966

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010161:1501758:150175815017581502723966Bartonella tribocorum CIP 105476, complete genomehypothetical protein1e-179628
NC_010161:1324381:132438113243811325346966Bartonella tribocorum CIP 105476, complete genomehypothetical protein1e-179628
NC_010161:1949637:195007819500781951043966Bartonella tribocorum CIP 105476, complete genomehypothetical protein1e-179628
NC_020301:853267:874258874258875223966Bartonella vinsonii subsp. berkhoffii str. Winnie, complete genomehypothetical protein2e-173608
NC_014034:3111981:311346831134683114442975Rhodobacter capsulatus SB1003 chromosome, complete genomehypothetical protein8e-81300
NC_016642:2440070:244144424414442442385942Pseudovibrio sp. FO-BEG1 chromosome, complete genomehypothetical protein4e-61234
NC_014307:1765230:176792317679231768849927Ralstonia solanacearum CFBP2957 chromosome, complete genomehypothetical protein9e-1477.8
NC_011750:2009889:202185220218522022805954Escherichia coli IAI39 chromosome, complete genomehypothetical protein5e-1375.5
NC_002927:3827211:384831238483123849259948Bordetella bronchiseptica RB50, complete genomehypothetical protein8e-0651.6