Pre_GI Gene

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Host: NC_011896 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011896:1462258 Mycobacterium leprae Br4923, complete genome

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
146225814652092952hypothetical proteinBLASTP
146563714667131077hypothetical proteinBLASTP
14668781467570693hypothetical proteinBLASTP
146760014693391740putative acyl-CoA synthaseQuickGO ontologyBLASTP
14765751477459885putative enoyl-CoA hydrataseisomeraseQuickGO ontologyBLASTP
14821571482618462hypothetical proteinBLASTP
148284114843161476hypothetical proteinBLASTP
148431314860521740putative transferaseQuickGO ontologyBLASTP
148604914883762328glycerol-3-phosphate acyltransferaseQuickGO ontologyBLASTP