Pre_GI Gene

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Host: NC_010516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010516:514000 Clostridium botulinum B1 str. Okra, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
514303515031729glutamine amidotransferase CobBCobQ familyQuickGO ontologyBLASTP
5150895164501362UDP-N-acetylmuramyl tripeptide synthetase homologQuickGO ontologyBLASTP
516715517695981mannose-6-phosphate isomerase class IQuickGO ontologyBLASTP
5180445191591116putative lipoproteinQuickGO ontologyBLASTP
519267520121855putative undecaprenol kinaseQuickGO ontologyBLASTP
520531522032150216S ribosomal RNAQuickGO ontologyBLASTP
52217552225278tRNA-AlaQuickGO ontologyBLASTP
52225752233377tRNA-IleQuickGO ontology
522406525307290223S ribosomal RNAQuickGO ontologyBLASTP
5254015255171175S ribosomal RNAQuickGO ontologyBLASTP
52552552560177tRNA-AsnQuickGO ontologyBLASTP
525978526841864metallo-beta-lactamase family proteinQuickGO ontologyBLASTP
526978527700723putative 1-acyl-sn-glycerol-3-phosphate acyltransferaseQuickGO ontologyBLASTP
5284465298071362HMGL-related enzymeQuickGO ontologyBLASTP
5299515318761926aconitaseisopropylmalate dehydratase family proteinQuickGO ontologyBLASTP
531912532910999dehydrogenase isocitrateisopropylmalate familyQuickGO ontologyBLASTP
533158533943786polar amino acid uptake family ABC transporter PAAT family ATP-binding proteinQuickGO ontologyBLASTP
5344675362331767NaH antiporter family proteinQuickGO ontologyBLASTP