Pre_GI Gene

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Host: NC_010520 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010520:496500 Clostridium botulinum A3 str. Loch Maree, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
496960497688729glutamine amidotransferase CobBCobQ familyQuickGO ontologyBLASTP
4977464991071362UDP-N-acetylmuramyl tripeptide synthetase homologQuickGO ontologyBLASTP
499372500352981mannose-6-phosphate isomerase class IQuickGO ontologyBLASTP
5007005018151116putative lipoproteinQuickGO ontologyBLASTP
501923502777855putative undecaprenol kinaseQuickGO ontologyBLASTP
503187504688150216S ribosomal RNAQuickGO ontologyBLASTP
50483150490878tRNA-AlaQuickGO ontologyBLASTP
50491350498977tRNA-IleQuickGO ontology
505063507964290223S ribosomal RNAQuickGO ontologyBLASTP
5080965082121175S ribosomal RNAQuickGO ontologyBLASTP
50822050829677tRNA-AsnQuickGO ontologyBLASTP
508756509619864metallo-beta-lactamase family proteinQuickGO ontologyBLASTP
509756510478723putative 1-acyl-sn-glycerol-3-phosphate acyltransferaseQuickGO ontologyBLASTP
5112245125851362HMGL-related enzymeQuickGO ontologyBLASTP
5127285146501923aconitaseisopropylmalate dehydratase family proteinQuickGO ontologyBLASTP
514888515886999dehydrogenase isocitrateisopropylmalate familyQuickGO ontologyBLASTP
516236517021786polar amino acid uptake family ABC transporter PAAT family ATP-binding proteinQuickGO ontologyBLASTP
5175405193061767NaH antiporter family proteinQuickGO ontologyBLASTP