Pre_GI Gene

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Host: NC_004557 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004557:558500 Clostridium tetani E88, complete genome

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
5586855604511767hypothetical protein
5606135617581146hypothetical proteinBLASTP
561864562679816undecaprenyl pyrophosphate phosphataseQuickGO ontologyBLASTP
562682563215534hypothetical protein
563306563947642hypothetical protein
564030564518489hypothetical protein
565000566508150916S ribosomal RNAQuickGO ontologyBLASTP
56665756673276tRNA-AlaQuickGO ontologyBLASTP
56674356681977tRNA-IleQuickGO ontology
567056569901284623S ribosomal RNAQuickGO ontologyBLASTP
568913569569657hypothetical proteinBLASTP
570080570165865S ribosomal RNAQuickGO ontologyBLASTP
57018657026075tRNA-AsnQuickGO ontology
570458571333876comE operon proteinQuickGO ontologyBLASTP
571575572303729putative 1-acyl-sn-glycerol-3-phosphate acyltransferaseQuickGO ontologyBLASTP
572773573228456hypothetical proteinBLASTP
573257573847591RNA polymerase sigma-70 factorQuickGO ontologyBLASTP
573822574796975hypothetical protein
5748415765711731signal-transduction and transcriptional-control proteinQuickGO ontologyBLASTP
576911577729819cystineglutamine-binding periplasmic proteinQuickGO ontologyBLASTP
577754578569816cystineglutamine-binding periplasmic proteinQuickGO ontologyBLASTP
578640579290651cystineglutamine permease proteinQuickGO ontologyBLASTP
579332580063732glutamine transport ATP-binding protein glnQQuickGO ontologyBLASTP
5801325813281197argininosuccinate synthaseQuickGO ontologyBLASTP
5814255827411317argininosuccinate lyaseQuickGO ontologyBLASTP