Pre_GI Island

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n1_4mer:GRV/n1_4mer:RV = (Global Relative Variance of OU patterns) / (Local Relative Variance of OU patterns)

n0_4mer:D = Distance between local and global OU patterns

n0_4mer:PS = Distance between 2 strands of same DNA molecule

Selected loci indicated by large D, increased GRV associated with decreased RV and moderate increase in PS




NC_008593: Clostridium novyi NT, complete genome

NCBI: NC_008593

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.



Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

#StartEndLengthIsland TextGRV_RVDPSNeighboursClusterSub ClusterBLASTNKey Word ConfirmationOther DB ConfirmationDownload Island
137456*6080623351Island text3.4025218.425736.7579Neighbours21BLASTN+37456.gbk
2153014*17175318740Island text4.1636916.667731.1548Neighbours21BLASTN153014.gbk
3196257*23516638910Island text3.5611616.514232.7171Neighbours21BLASTN196257.gbk
4555463*57939123929Island text2.2881218.855731.0523Neighbours21BLASTN+555463.gbk
560972363291123189Island text4.6996916.5431.8736Neighbours21BLASTN+609723.gbk
6640000*66264322644Island text2.3105616.147929.3093Neighbours21BLASTN+640000.gbk
784129186462123331Island text2.4495315.995929.8027Neighbours21BLASTN841291.gbk
8980731100500724277Island text3.2264515.132535.9118Neighbours21BLASTN980731.gbk
91060548108560225055Island text3.7544916.529232.0317Neighbours21BLASTN1060548.gbk
101103293112464521353Island text4.792317.666137.0691Neighbours21BLASTN1103293.gbk
111362218138346221245Island text3.4412116.899733.509Neighbours21+1362218.gbk
121461771*148498223212Island text3.5804116.591729.4372Neighbours21BLASTN+1461771.gbk
131513107153682423718Island text3.7142815.652435.2905Neighbours21BLASTN+1513107.gbk
141631438165059619159Island text3.1310116.391132.3243Neighbours21BLASTN+1631438.gbk
151704207*172452320317Island text4.6425316.72335.9499Neighbours21BLASTN1704207.gbk
161797000*182201325014Island text5.0532619.861840.8479Neighbours21BLASTN+1797000.gbk
171859861188348723627Island text1.8158617.397631.4838Neighbours21BLASTN1859861.gbk
181917118*196528648169Island text4.9638118.806235.0343Neighbours21BLASTN+1917118.gbk
192020473*204359923127Island text7.1181819.780840.8174Neighbours21BLASTN2020473.gbk
202136759215512718369Island text3.0506917.096331.767Neighbours21BLASTN2136759.gbk
212250871226893418064Island text4.2204516.242135.0347Neighbours21BLASTN2250871.gbk
222281896230590024005Island text3.0964216.041531.6177Neighbours21BLASTN2281896.gbk
232457594*250471047117Island text6.1856720.700943.0254Neighbours21BLASTN+2457594.gbk
242527064*255549928436Island text7.7204922.717745.2839Neighbours21BLASTN2527064.gbk