Pre_GI Gene

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Host: NC_008593 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008593:841291 Clostridium novyi NT, complete genome

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
8412918425231233protonglutamate symporterQuickGO ontologyBLASTP
8427408440711332Predicted membrane proteinQuickGO ontologyBLASTP
844089844808720phospholipase C related proteinQuickGO ontologyBLASTP
844964845491528hypothetical proteinBLASTP
8454518472231773magnesium-protoporphyrin IX monomethyl ester oxidative cyclaseQuickGO ontologyBLASTP
847460847795336V-type sodium ATP synthase subunit GQuickGO ontologyBLASTP
8477828497371956V-type sodium ATP synthase subunit IQuickGO ontologyBLASTP
849827850327501V-type sodium ATP synthase subunit KQuickGO ontologyBLASTP
850364850960597ATP synthase E31 kDa subunitQuickGO ontologyBLASTP
8509748519751002ATP synthase CAC39 subunitQuickGO ontologyBLASTP
851968852276309ATP synthase F14-kDa subunitQuickGO ontologyBLASTP
8522958540701776V-type sodium ATP synthase subunit AQuickGO ontologyBLASTP
8540638554451383V-type sodium ATP synthase subunit BQuickGO ontologyBLASTP
855448856098651V-type ATPase D subunitQuickGO ontologyBLASTP
856270856746477peptide deformylaseQuickGO ontologyBLASTP
856893857402510hypothetical proteinBLASTP
857553857891339hypothetical proteinBLASTP
8579148601992286superfamily I DNA helicaseQuickGO ontologyBLASTP
8602408614271188flavodoxin putativeQuickGO ontologyBLASTP
862020862988969fructose-16-bisphosphatase class IIQuickGO ontologyBLASTP
863163864086924HPr kinasephosphorylaseQuickGO ontologyBLASTP
8640708646215525-formyltetrahydrofolate cyclo-ligase family proteinQuickGO ontologyBLASTP