Pre_GI Gene

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Host: NC_008593 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008593:196257 Clostridium novyi NT, complete genome

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
196257197000744TPR Domain proteinQuickGO ontologyBLASTP
1971701985551386Xaa-His dipeptidase putativeQuickGO ontologyBLASTP
1986771999181242major facilitator superfamily proteinQuickGO ontologyBLASTP
200097200708612uncharacterized membrane proteinQuickGO ontologyBLASTP
200850201848999Peptidase family T4QuickGO ontologyBLASTP
202087202638552rubrerythrinQuickGO ontologyBLASTP
202869203327459transcription regulator ctsRQuickGO ontologyBLASTP
203395203919525hypothetical proteinBLASTP
2039312049651035Hypothetical ATPguanido phosphotransferaseQuickGO ontologyBLASTP
2049942074352442Negative regulator of genetic competence clpCmecBQuickGO ontologyBLASTP
2075992089601362DNA repair protein RadAQuickGO ontologyBLASTP
2089922100591068Domain of unknown function DUF147 family proteinQuickGO ontologyBLASTP
210096210497402hypothetical proteinBLASTP
2108032118821080Membrane-associated proteinQuickGO ontologyBLASTP
2119052126006962-C-methyl-D-erythritol 4-phosphate cytidylyltransferaseQuickGO ontologyBLASTP
2128072142071401cysteinyl-tRNA synthetaseQuickGO ontologyBLASTP
214312214725414hypothetical proteinBLASTP
214749215483735thymidylate synthase flavin-dependentQuickGO ontologyBLASTP
215516216313798RNA methyltransferase TrmH family group 3QuickGO ontologyBLASTP
216323216829507hypothetical proteinBLASTP
216937217596660RNA polymerase sigma-H factorQuickGO ontologyBLASTP
21772821780376tRNA-ThrQuickGO ontologyBLASTP
2178972190781182translation elongation factor TuQuickGO ontologyBLASTP
219566219787222Preprotein translocase secE subunitQuickGO ontologyBLASTP
219908220429522transcription terminationantitermination factor NusGQuickGO ontologyBLASTP
220503220928426ribosomal protein L11QuickGO ontologyBLASTP
220982221680699ribosomal protein L1QuickGO ontologyBLASTP
22187822238150450S ribosomal protein L10QuickGO ontologyBLASTP
222428222793366ribosomal protein L7L12QuickGO ontologyBLASTP
2230622267873726DNA-directed RNA polymerase beta subunitQuickGO ontologyBLASTP
2267872303443558DNA-directed RNA polymerase beta subunitQuickGO ontologyBLASTP
230467230709243ribosomal protein L7AE family putativeQuickGO ontologyBLASTP
230765231142378ribosomal protein S12QuickGO ontologyBLASTP
231274231744471ribosomal protein S7QuickGO ontologyBLASTP
2318572339202064translation elongation factor GQuickGO ontologyBLASTP
2339852351661182translation elongation factor TuQuickGO ontologyBLASTP