Pre_GI: BLASTN Hits

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Query: NC_008593:2136759 Clostridium novyi NT, complete genome

Start: 2136759, End: 2155127, Length: 18369

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_004557:25524182552418257431921902Clostridium tetani E88, complete genome0779BLASTN svgBLASTP svg
NC_012563:37298173729817376659036774Clostridium botulinum A2 str. Kyoto, complete genome0710BLASTN svgBLASTP svg
NC_010520:35800003580000360470824709Clostridium botulinum A3 str. Loch Maree, complete genome0686BLASTN svgBLASTP svg
NC_010723:62292862292864247719550Clostridium botulinum E3 str. Alaska E43, complete genome0674BLASTN svgBLASTP svg
NC_010674:65859665859667712118526Clostridium botulinum B str. Eklund 17B, complete genome0674BLASTN svgBLASTP svg
NC_010674:31412283141228316494623719Clostridium botulinum B str. Eklund 17B, complete genome0664BLASTN svgBLASTP svg
NC_008262:24980002498000252144223443Clostridium perfringens SM101, complete genome2e-179636BLASTN svgBLASTP svg
NC_010516:35450173545017356809923083Clostridium botulinum B1 str. Okra, complete genome2e-164587BLASTN svgBLASTP svg
NC_021182:14735351473535149659923065Clostridium pasteurianum BC1, complete genome6e-155555BLASTN svgBLASTP svg
NC_010674:37062937062939810727479Clostridium botulinum B str. Eklund 17B, complete genome2e-139504BLASTN svgBLASTP svg
NC_014393:36509573650957366964218686Clostridium cellulovorans 743B chromosome, complete genome4e-131476BLASTN svgBLASTP svg
NC_010723:37174137174139352221782Clostridium botulinum E3 str. Alaska E43, complete genome2e-130474BLASTN svgBLASTP svg
NC_020291:49100049100051106420065Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome1e-63252BLASTN svgBLASTP svg
NC_014328:43160084316008434476228755Clostridium ljungdahlii ATCC 49587 chromosome, complete genome2e-53218BLASTN svgBLASTP svg
NC_015275:3594890*3594890363588740998Clostridium lentocellum DSM 5427 chromosome, complete genome4e-45190BLASTN svgBLASTP svg
NC_015958:677500*67750069545217953Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genome3e-39170BLASTN svgBLASTP svg
NC_011898:426951*42695146616239212Clostridium cellulolyticum H10, complete genome1e-38168BLASTN svgBLASTP svg
NC_010718:46440546440548434419940Natranaerobius thermophilus JW/NM-WN-LF, complete genome6e-19103BLASTN svgBLASTP svg
NC_014328:77309577309579175318659Clostridium ljungdahlii ATCC 49587 chromosome, complete genome4e-1797.6BLASTN svgBLASTP svg
NC_019978:31534631534633383318488Halobacteroides halobius DSM 5150, complete genome4e-1797.6BLASTN svgBLASTP svg
NC_011567:1*13972539725Anoxybacillus flavithermus WK1, complete genome6e-1693.7BLASTN svgBLASTP svg
NC_010520:21715842171584219449022907Clostridium botulinum A3 str. Loch Maree, complete genome1e-1489.7BLASTN svgBLASTP svg
NC_009850:41309341309343688323791Arcobacter butzleri RM4018, complete genome1e-1489.7BLASTN svgBLASTP svg
NC_010723:57525457525460199426741Clostridium botulinum E3 str. Alaska E43, complete genome4e-1487.7BLASTN svgBLASTP svg
NC_010516:20640272064027208498120955Clostridium botulinum B1 str. Okra, complete genome2e-1281.8BLASTN svgBLASTP svg
NC_020164:88751088751091047422965Staphylococcus warneri SG1, complete genome9e-1279.8BLASTN svgBLASTP svg
NC_019978:39000*390005838419385Halobacteroides halobius DSM 5150, complete genome4e-1177.8BLASTN svgBLASTP svg
NC_010674:61596361596363966223700Clostridium botulinum B str. Eklund 17B, complete genome4e-1177.8BLASTN svgBLASTP svg
NC_004545:15650*156506959953950Buchnera aphidicola str. Bp (Baizongia pistaciae), complete genome6e-1073.8BLASTN svgBLASTP svg
NC_003869:1643682*1643682167230228621Thermoanaerobacter tengcongensis MB4, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_002758:43446243446245281818357Staphylococcus aureus subsp. aureus Mu50, complete genome2e-0971.9BLASTN svgBLASTP svg
NC_014328:26435882643588266721023623Clostridium ljungdahlii ATCC 49587 chromosome, complete genome2e-0971.9BLASTN svgBLASTP svg
NC_013192:1765981*1765981178974923769Leptotrichia buccalis DSM 1135, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_011296:102650*10265012914226493Thermodesulfovibrio yellowstonii DSM 11347, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_007681:1455425*1455425147908523661Methanosphaera stadtmanae DSM 3091, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_009828:469778*46977851143441657Thermotoga lettingae TMO, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_015638:31132533113253313625323001Lacinutrix sp. 5H-3-7-4 chromosome, complete genome1e-0765.9BLASTN svgBLASTP svg
NC_015949:2002752*2002752202359920848Caldicellulosiruptor lactoaceticus 6A chromosome, complete genome1e-0765.9BLASTN svgBLASTP svg
NC_021184:65709365709368009923007Desulfotomaculum gibsoniae DSM 7213, complete genome1e-0765.9BLASTN svgBLASTP svg
NC_014932:1232346*1232346130968277337Bartonella clarridgeiae 73, complete genome5e-0763.9BLASTN svgBLASTP svg
NC_012563:22030372203037222476521729Clostridium botulinum A2 str. Kyoto, complete genome5e-0763.9BLASTN svgBLASTP svg
NC_006156:685344*68534470851723174Borrelia garinii PBi chromosome linear, complete sequence5e-0763.9BLASTN svgBLASTP svg
NC_004557:2289135*2289135231328724153Clostridium tetani E88, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_007681:48244548244550728724843Methanosphaera stadtmanae DSM 3091, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_012440:197728*19772822123323506Persephonella marina EX-H1, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_014833:97931*9793111843720507Ruminococcus albus 7 chromosome, complete genome9e-0660BLASTN svgBLASTP svg
NC_013407:1205747*1205747123302227276Methanocaldococcus vulcanius M7, complete genome9e-0660BLASTN svgBLASTP svg
NC_004668:3156247*3156247318179425548Enterococcus faecalis V583, complete genome9e-0660BLASTN svgBLASTP svg
NC_000964:64978164978166954019760Bacillus subtilis subsp. subtilis str. 168, complete genome9e-0660BLASTN svgBLASTP svg